The below information on Aciphex has been taken from official FDA sources, but we cannot guarantee it's accuracy. Please use this site for educational purposes only. This site does not replace a proper discussion with your doctor.

    Brand Name:Aciphex
    Generic:Rabeprazole Sodium
This drug was approved by the FDA in one form or another on:
1999-08-19 ,
This drug is made in one form or another by the following companies:
Eisai Inc.
This drug is available in the following forms:
View the actual FDA approved label for this drug at the following links:

About Aciphex

Aciphex is used for:

  • short-term healing of a gradual breakdown (erosion) or sore (ulceration) in the esophagus which may be caused by the backward flow of gastric acid from the stomach into the esophagus (gastroesophageal reflux disease or GERD);
  • maintenance of healing of erosive or ulcerative GERD;
  • treatment of daytime and nighttime heartburn and other symptoms associated with GERD;
  • short-term (up to 4 weeks) healing of an ulcer in the duodenum;
  • elimination of Helicobacter pylori, in combination with amoxicillin and clarithromycin, to reduce the risk of duodenal ulcer recurrence in patients with a current duodenal ulcer or a duodenal ulcer in the past 5 years;
  • medical conditions that result in the body secreting too much acid, including Zollinger-Ellison syndrome.

Precautions for Aciphex

Aciphex does not work for everyone. Improvement in your symptoms does not prevent you from having other stomach-related medical conditions.

Side Effects of Aciphex

Aciphex is generally well tolerated. The most common side effect is headache.

Your health care provider can discuss with you a complete list of possible side effects.

For more detailed information about Aciphex, ask your health care provider.

Who Should Not Take Aciphex

Do NOT use Aciphex if:

  • you are allergic to any ingredient in Aciphex

Contact your doctor or health care provider right away if any of these apply to you.

Interactions with Aciphex

If Aciphex is taken with certain other drugs, the effects of either could be increase, decreased, or altered. It is especially important to check with your doctor before combining AcipHex with the following:

  • Cyclosporine (Neoral, Sandimmune)
  • Digoxin (Lanoxin)
  • Ketoconazole (Nizoral)
  • Warfarin (Coumadin)
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Recent Forum Posts on Aciphex

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I too suffer with Gerd

I have gone through all the acid reducer ppi's and have terrible side effects from all of them. The least problems come from taking Aciphix except for the high cost and terrible headache's.I have been considering calling the doctor and looking into the new operation called TIF procedure. It totally eliminates gerd and has only a few day recovery time using a EsophyX device. Has any of you had this done? Let me know how things turned out and if Gerd is a thing of the past for you.

No Subject

I have been on aciphex for about a year now. It has worked with
no problems. Here lately I have been experiencing a growling rumbling stomach. It gets to be so loud it wakes me at night. I have also been
having trouble sleeping. Any ideas???

Sudden onset of burning in the throat area.

My doctor prescribed me aciphex after I went to her with a very bad burning sensation in the throat area in wich was a very sudden onset, nothing I did would help except I noticed drinking very cold stuff eased the pain only for a few minutes at a time. Nothing over the counter worked.Aciphex definately helps, however I was tested for H.Pylori and it came back posotive, I was treated with what is called the prev-pack for 14 days, after finishing the prev-pack and all of the aciphex the symptoms returned after a day. Now I am going to have an EGD done, but I am worried about what this could be. Could the sudden onset of this be something that has ruptured, could it possibly be a hiatal hernia, I just dont know. I have had other symptoms within the past year such as having trouble breathing at times, I have went to the ER, and a couple of doctors and they just tell me its anxiety.


I'd like to slap the doctor who removed my hyatial (sp) 'ring'... sure it was hard to swallow when I didn't chew well or eat slowly, but at least those were healthy eating habits an were much better compared to the daily dose of aciphex i'm doomed to take for the rest of my life. I truly believe these doctors get some sort of kick-back for starting people on expensive drugs and that they are interested in 'maintaining' people (revenue) rather than curing them. I hate being on this pill, and I hate the side-effects, and am searching for natural methods and lifestyle to control my reflux. The long term effects of this drug have not been studied past five years, yet doctors encourage people to become dependent on it rather than help people change to a diet and lifestyle that would control their reflux naturally. Whenever I ask a doctor about controlling reflux naturally, I get a blank stare (deer caught in headlights), as if I've committed a mortal sin by suggesting that pills are not the ultimate answer to every malady. Anyway, enough of my rant, if any of you have successfully been rehabed from the refulx pill addiction culture through natural methods please let me know. M 36 6 years on aciphex

just started aciphex

hi i just started taking aciphex today, doctor gave me this to take along with an anti-inflammatory drug, which would ALWAYS upset my stomach. I can't take those drugs, like advil, motrin aspirin since I had an ulcer along time ago. They really upset my stomach. So he gave me Bextra for my back pain and arthritis. and also Aciphex to calm my stomach, and I AM SO HAPPY IT WORKS!!!!!!!!!! My arthritis and back pain is feeling better and my stomach feels fine. Anyone else in this boat?
thanks, Nancy


I have been taking 40mg Aciphex for 1 month for suspected GERD. 20mg just doesn't work for me. The heartburn pain is daily and overwhelming. I just had an endoscopy that showed absolutely nothing wrong. The GI dr. blew me off and said there was no evidence of reflux and referred me back to my primary physician. I'm happy there's no damage...BUT...I still have daily heartburn pain. I've added 225mg. Zantac to my daily meds. The heartburn is better but still there and if I try to go down to 20mg. it returns as strong as ever. I use antacids daily which help but the liquid antacids give me diarrhea. I'm frustrated.

No Subject

I have had these symptoms sometimes 2 or 3 times a week: I feel faint, with a constricting feeling under my breast bone. No pain. I have worn a Holter monitor for 24 hrs with a negative result. I have had a stress test with negative results. Meaning no problem with my heart. My doctor recently prescribed Aciphex, to be taken for 2 weeks for this. Any comments?


I have been on Aciphex now for about a month..I take 40 mg. twice a day with a 350 mg. Zantac at noon. I have noticed a clear difference with my acid production. It no longer keeps me awake at night; jsut the morning. The amount of acid/bile that I regurgitate has decreased also. The side effects for me have been limited to only headaches which is better that the severe causes of nausea and vomitting i was having. I recently switched to this medication after taking all other acid reducers: Nexium, Prilosec, Prevacid, Protonix and I will say that this is best. I have been diagnosed with Barrets Esophagus, pre-cancerous cells on both teh stomach and the esophagus, and have Gastro-Pareisis (paralization of the stomach). So, I truly reccommend this product. If oyu have any further questions feel free to email me.

just started aciphex

I just started aciphex yesturday, March 9,2004. I have been experiencing chest pains and back pains along with mild heartburn. Last year I was on Omeprazole up until last week. The pain in my chest was so painfull. My doctor now put me on this. He told me it would take a couple of weeks to see if it will work. I sure hope this one helps!


I just started taking Aciphex last week. My doctor prescribe it to me because I have been having incredible chest pains. Over the past three years I have had to deal with these pains. After two days of taking this medicine my pains have disappeard. Finally. I have experienced some side effects: headaches, leg cramps and sleeplessness.


I started taking Aciphex about four days ago and I have felt a small amount of relief from chronic gas pains and discomfort (e.g., burning, sharp pains). I am wondering how long does this medication generally take before significant relief is generally felt?

Why not long term?


My Mother takes Aciphex, long term though, would someone mind E-mailing me why this should only be taken short-term? She has been on it for about 7 months now and I am alittle worried after reading it is only for short-term usage.

I was also considering it, I also have a wonderful (yeah right) insurance company that makes me go through "expereiments" also before getting the drug that my doctor prescribes, they refused Nexium and put me on over the counter Prilo. why? Because it is cheaper! Ahh!

Thanks for any help!


hiatal hernia & gerd

I was diagnosed with GERD and hiatal hernia after endoscopy procedure. I am somewhat better but still have some shortness of breath. Very scary stuff!! Any ideas???

No Subject

I am currently taking Serzone and just read that I should not take any heartburn medication while using Serzone. Is aciphex dangerous for me, if so why, what are the dangers and what are the symptoms that I would be having if there were a problem from using the Serzone and aciphex at the same time? Thanks


i have been taking asiphex for 2 years fo GERD and hiatal hernia and have no side effects from it. it does wonders for me, no reflux or pain any more, thats a relief.


I was recntly diagnosed with GERD after suffereing from severe heartburn and stomach pain after going to the er i had been prescribed aciphex previously never took it, but they gave me over the counter pepcid it did nothing to me, so i decided to take the aciphex my pcp had prescribed i have been using for 2 months now i have no side effects and it is wonderful i feel so much better now and i just have to watch what i eat but other than that aciphex saved me!! but is that true that a prolongue use of aciphex can be dangerous.

No Subject

I was given samples of Aciphex by my doctor to try. He believed I had GERD. Within two days I developed itchy skin and sun sensitivity. My new doctor prescribed Ranitidine which has the same result. I don't appear to be capable of taking any of these drugs. I am allergic to Aciphex, Ranitidine, Nexium, Prilosec etc.
I am going it drug-free now. The side effects such as increased risk of pneumonia really scare me. Having had pneumonia once, I refuse to take a drug which can make me that sick.
So far, my low-fat,no-acid, no coffee, no tomato diet seems to really work. I know its a pain to give up foods I love, but its better than being sick.


OK i just wanna know if i'm supposed to eat with this pill i dont know what to do because if i dont eat with it something might go wrong and if i do the same thing... some one help me please


It has been a life saver with me. I have been on it for 6-7 years now, with no side effects. I had gerd so bad that a glass of water would trigger heartburn. As long as I take my pills daily I can live a normal and healthy life, able to eat what I want.

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