The below information on Actimmune has been taken from official FDA sources, but we cannot guarantee it's accuracy. Please use this site for educational purposes only. This site does not replace a proper discussion with your doctor.

    Brand Name:Actimmune
    Generic: Interferon Gamma-1B
This drug was approved by the FDA in one form or another on:
1999-02-25 ,
This drug is made in one form or another by the following companies:
Intermune Pharmaceuticals, Inc.
This drug is available in the following forms:
View the actual FDA approved label for this drug at the following links:

About Actimmune

Interferon gamma-1b is made from human proteins. Interferons help the body fight viral infections.

Interferon gamma-1b is a specific interferon used to prevent infections in people with a condition called chronic granulomatous disease. Interferon gamma-1b is also used to treat a congenital bone disorder called osteopetrosis.

Interferon gamma-1b may also be used for purposes other than those listed in this medication guide.

Precautions for Actimmune

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects.

This medicine commonly causes a flu-like reaction, with aching muscles, fever and chills, and headache. To prevent problems from your temperature going too high, your doctor may ask you to take acetaminophen before each dose of gamma interferon. You may also need to take it after a dose to bring your temperature down. Follow your doctor's instructions carefully about taking your temperature, and how much and when to take the acetaminophen.

Side Effects of Actimmune

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

  • Diarrhea; fatigue;
  • flu-like symptoms (eg, low-grade fever, chills, general body discomfort);
  • headache;
  • joint pain;
  • muscle pain;
  • nausea;
  • pain, redness, or swelling at the injection site;
  • tiredness; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

  • Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue);
  • chest pain;
  • confusion;
  • dizziness;
  • fainting;
  • fast or irregular heartbeat;
  • high or persistent fever;
  • mood or mental changes;
  • seizures;
  • signs of infection (eg, chills, persistent sore throat);
  • stomach pain;
  • trouble walking;
  • unusual bruising or bleeding;
  • yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider.

Who Should Not Take Actimmune

Do NOT use Actimmune if:

  • you are allergic to any ingredient in Actimmune or to any medicine derived from Escherichia coli

Contact your doctor or health care provider right away if any of these apply to you.

Interactions with Actimmune

Live virus vaccines (eg, measles, mumps, polio, rubella)

May inhibit antibody response after immunization; avoid concurrent use.

Myelosuppressive agents

Additive neutropenic effects are possible.

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