Actoplus MET

The below information on Actoplus MET has been taken from official FDA sources, but we cannot guarantee it's accuracy. Please use this site for educational purposes only. This site does not replace a proper discussion with your doctor.

    Brand Name:Actoplus MET
    Generic:Metformin Hydrochloride, Pioglitazone Hydrochloride
This drug was approved by the FDA in one form or another on:
2005-08-29 ,
This drug is made in one form or another by the following companies:
Takeda Global Research & Development Center, Inc.
This drug is available in the following forms:
View the actual FDA approved label for this drug at the following links:,021842s002lbl.pdf

About Actoplus MET

ActoPlus Met is used for:

Improving blood sugar levels, with diet and exercise, in patients with type 2 diabetes who are already being treated with both of these medications, who are not adequately controlled on metformin alone, or who have responded to pioglitazone alone but require additional control.

ActoPlus Met is a combination of an insulin resistance reducer and a biguanide. This combination medicine works in 2 ways to improve blood glucose levels (sugar). Pioglitazone helps the cells use glucose, and metformin slows the liver's production of glucose. Controlling high blood sugar helps prevent heart disease, strokes, kidney disease, blindness, circulation problems, and sexual function problems (impotence).

Side Effects of Actoplus MET

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

  • Diarrhea;
  • metallic taste;
  • weight gain.
Seek medical attention right away if any of these SEVERE side effects occur:
  • Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue);
  • abdominal or stomach pain;
  • appetite loss;
  • fluid retention;
  • heart problems;
  • liver problems (dark urine, yellowing of the skin or eyes);
  • muscle pain;
  • nausea;
  • rapid weight gain;
  • shortness of breath;
  • vomiting;
  • unusual tiredness or weakness.

Who Should Not Take Actoplus MET

Do NOT use ActoPlus Met if:

  • you are allergic to any ingredient in ActoPlus Met
  • you have kidney problems
  • you have type 1 diabetes; lactic acidosis; metabolic acidosis, including diabetic ketoacidosis; or diabetic coma
  • you have congestive heart failure that requires treatment with medications

Contact your doctor or health care provider right away if any of these apply to you.

Interactions with Actoplus MET

Some MEDICINES MAY INTERACT with ActoPlus Met . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Rifampin because the effectiveness of ActoPlus Met may be decreased
  • Angiotensin-converting enzyme (ACE) inhibitors (eg, captopril), cimetidine, gemfibrozil, or maprotiline because the actions and side effects of ActoPlus Met may be increased and very low blood sugar may occur
  • Iodine-containing radiopaque agents used for x-ray or scanning procedures because the risk of sudden kidney failure may be increased and lactic acidosis may occur. ActoPlus Met should not be used within 48 hours of iodine-containing radiopaque agents
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, celecoxib) because the risk of sudden kidney failure and lactic acidosis may be increased
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Recent Forum Posts on Actoplus MET

drug test

I'am a diabetic and I take actoplus Met 850mg twice daILY FOR MY HIGH SUGAR LEVELS,I would like to ask you a question , last week I had to take a drug test, it was a saliva drug test, well today I called for the results and the lady said I was postive for cocaine , even though I do not do drug and I have never have done any form of drugs, I've been looking on the internet, and alot of websites say thatthis can happen in diabetics. what I like to know is can this be trur do to the fact that I take actoplus met , can this medicine show traces of cocaine.Can you please contact me

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