The below information on Aptivus has been taken from official FDA sources, but we cannot guarantee it's accuracy. Please use this site for educational purposes only. This site does not replace a proper discussion with your doctor.

    Brand Name:Aptivus
    Generic: Tipranavir
This drug was approved by the FDA in one form or another on:
2005-06-22 ,
This drug is made in one form or another by the following companies:
Boehringer Ingelheim Pharmaceuticals
This drug is available in the following forms:
View the actual FDA approved label for this drug at the following links:

About Aptivus

Aptivus is a medicine called a “protease inhibitor” that is used to treat adults with Human Immunodeficiency Virus (HIV). Aptivus blocks HIV protease, an enzyme which is needed for HIV to make more virus. When used with other anti-HIV medicines, Aptivus may reduce the amount of HIV in your blood and increase the number of CD4+ cells. Reducing the amount of HIV in the blood may keep your immune system healthy so it can help fight infection. Aptivus is always taken with Norvir (ritonavir) and at the same time as Norvir. When you take Aptivus with Norvir, you must always use at least 2 other anti-HIV medicines.

Aptivus does not cure HIV infection or AIDS. You may still get infections or other conditions common in people with HIV. Aptivus does not reduce the chance of passing HIV to others through sexual contact, sharing needles, or being exposed to your blood.

Side Effects of Aptivus

Aptivus can cause serious problems such as:

  • Liver problems, including liver failure and death. Your doctor should do blood tests to monitor your liver function during treatment with Aptivus. Patients with liver diseases such as Hepatitis B and Hepatitis C may have worsening of their liver disease with Aptivus and should have blood tests more often.
  • Rash. Mild to moderate rash, including flat or raised rashes or sensitivity to the sun, have been reported in approximately 10% of patients receiving Aptivus. Some patients who developed rash also had joint pain or stiffness, throat tightness, or generalized itching.
  • Increased bleeding in patients with hemophilia. This can happen in patients taking Aptivus or other protease inhibitor medicines.
  • Diabetes and high blood sugar (hyperglycemia). This can happen in patients taking Aptivus or other protease inhibitor medicines. Some patients have diabetes before starting treatment with Aptivus which gets worse. Some patients develop diabetes during treatment with Aptivus. Some patients will need new diabetes medicine or changes in their current diabetes medicine.
  • Increased blood fat (lipid) levels. Your doctor should do blood tests to monitor your blood fat (triglycerides and cholesterol) during treatment with Aptivus. Some patients taking Aptivus have large increases in triglycerides and cholesterol. The long-term chance of having a heart attack or stroke due to increases in blood fats caused by Aptivus is not known at this time.
  • Changes in body fat. These changes have happened in patients taking Aptivus and other anti-HIV medicines. The changes may include an increased amount of fat in the upper back and neck (“buffalo hump”), breast, and around the back, chest, and stomach area. Loss of fat from the legs, arms, and face may also happen. The cause and long-term health effects of these conditions are not known.
  • Common side effects such as diarrhea, nausea, vomiting, stomach pain, tiredness, and headache. Women taking birth control pills may get a skin rash. You should report any new or continuing symptoms to your doctor right away. The list of side effects is not complete. Ask your healthcare professional for more information.

Who Should Not Take Aptivus

Do not take Aptivus if you:

  • are allergic to tipranavir or any of the other ingredients in Aptivus.
  • are allergic to ritonavir (Norvir).
  • have moderate to severe liver problems.
  • take any of the following types of medicines because you could have serious side effects:
    • Migraine (headache) medicines called “ergot alkaloids”. If you take migraine medicines, ask a healthcare professional if any of them are “ergot alkaloids”.
    • Halcion (triazolam)
    • Hismanal (astemizole)
    • Orap (pimozide)
    • Propulsid (cisapride)
    • Seldane (terfenadine)
    • Versed (midazolam)
    • Pacerone (amiodarone)
    • Vascor (bepridil)
    • Tambocor (flecainide)
    • Rythmol (propafenone)
    • Quinaglute (quinidine)

Interactions with Aptivus

Tell your healthcare professional about all the medicines you take including prescription and nonprescription medicines, vitamins and herbal supplements. Aptivus and many other medicines can interact. Sometimes serious side effects will happen if Aptivus is taken with certain other medicines (see “Who Should Not Take Aptivus?”).

Women taking birth control pills need to use another birth control method. Aptivus makes birth control pills work less well.

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