The below information on Arthrotec has been taken from official FDA sources, but we cannot guarantee it's accuracy. Please use this site for educational purposes only. This site does not replace a proper discussion with your doctor.

    Brand Name:Arthrotec
    Generic:Diclofenac Sodium, Misoprostol
This drug was approved by the FDA in one form or another on:
1997-12-24 ,
This drug is made in one form or another by the following companies:
G.D. Searle & Company
This drug is available in the following forms:
Tablets, Delayed Release
View the actual FDA approved label for this drug at the following links:

About Arthrotec

Arthrotec is used for:

Treating joint swelling, pain, and stiffness caused by osteoarthritis or rheumatoid arthritis in patients who are at a high risk of developing NSAID-induced ulcers or their complications. It may also be used for other conditions as determined by your doctor.

Arthrotec is an NSAID and prostaglandin analog combination. The prostaglandin maintains prostaglandin activity needed to protect the lining of the stomach and reduce acid secretion, reducing the risk of ulcers. The NSAID decreases prostaglandins that cause pain and inflammation, relieving joint pain.

Side Effects of Arthrotec

Possible side effects of Arthrotec :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

  • Diarrhea;
  • dizziness;
  • drowsiness;
  • gas;
  • headache;
  • indigestion;
  • nausea;
  • stomach pain;
  • swelling;
  • upset stomach;
  • vomiting.
Seek medical attention right away if any of these SEVERE side effects occur:
  • Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue);
  • black, tarry stools;
  • bleeding and ulcers in the stomach and intestines;
  • dark urine;
  • fever;
  • heart failure;
  • increase in asthma attacks;
  • increased liver injury;
  • loss of appetite;
  • severe diarrhea;
  • sore throat;
  • trouble breathing;
  • unusual bleeding or bruising;
  • vaginal bleeding after menopause;
  • vision or hearing problems;
  • vomit that looks like coffee grounds;
  • weight loss;
  • yellowing of the skin or eyes.

Who Should Not Take Arthrotec

Do NOT use Arthrotec if:

  • you are allergic to any ingredient in Arthrotec or other prostaglandins
  • you are pregnant
  • you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to aspirin or an NSAID (eg, ibuprofen, naproxen, celecoxib)

Contact your doctor or health care provider right away if any of these apply to you.

Interactions with Arthrotec

Some MEDICINES MAY INTERACT with Arthrotec . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticoagulants (eg, warfarin), heparin, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine, paroxetine) because the risk of side effects, such as bleeding, may be increased
  • Cyclosporine or methotrexate because the risk of toxicity may be increased
  • Lithium because the risk of its side effects may be increased by Arthrotec
  • Quinolone antibiotics (eg, ciprofloxacin) because the risk of side effects, such as seizures, may be increased
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