The below information on Avandamet has been taken from official FDA sources, but we cannot guarantee it's accuracy. Please use this site for educational purposes only. This site does not replace a proper discussion with your doctor.

    Brand Name:Avandamet
    Generic:Rosiglitazone Maleate, Glimepiride
This drug was approved by the FDA in one form or another on:
2005-11-23 ,
This drug is made in one form or another by the following companies:
SB Pharmco
This drug is available in the following forms:
View the actual FDA approved label for this drug at the following links:

About Avandamet

Avandamet is used for:

Improving blood sugar levels, with diet and exercise, in patients with type 2 diabetes who are already being treated with both of these medicines or who are not adequately controlled on metformin alone.

Avandamet is a combination of an insulin resistance reducer and a biguanide. This combination medicine works in 2 ways to improve blood glucose levels (sugar). Rosiglitazone helps the cells use glucose, and metformin slows the liver's production of glucose. Controlling high blood sugar helps prevent heart disease, strokes, kidney disease, blindness, circulation problems, and sexual function problems (impotence).

Side Effects of Avandamet

Possible side effects of Avandament :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

  • Diarrhea;
  • metallic taste;
  • trauma;
  • weight gain.
Seek medical attention right away if any of these SEVERE side effects occur:
  • Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue);
  • abdominal or stomach pain;
  • appetite loss;
  • fluid retention;
  • heart problems;
  • liver problems (dark urine, yellowing of the skin or eyes);
  • muscle pain;
  • nausea;
  • rapid weight gain;
  • shortness of breath;
  • vision changes;
  • vomiting;
  • unusual tiredness or weakness.

Who Should Not Take Avandamet

Do NOT use Avandamet if:

  • you are allergic to any ingredient in Avandamet
  • you have kidney problems
  • you have type 1 diabetes; lactic acidosis; metabolic acidosis, including diabetic ketoacidosis; or diabetic coma
  • you have congestive heart failure that requires treatment with medications

Contact your doctor or health care provider right away if any of these apply to you.

Interactions with Avandamet

Some MEDICINES MAY INTERACT with Avandamet . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Rifampin because the effectiveness of Avandamet may be decreased
  • Angiotensin-converting enzyme (ACE) inhibitors (eg, captopril), cimetidine, gemfibrozil, and maprotiline because the actions and side effects of Avandamet may be increased and very low blood sugar may occur
  • Iodine-containing radiopaque agents used for x-ray or scanning procedures because the risk of sudden kidney failure may be increased and lactic acidosis may occur. Avandamet should not be used within 48 hours of iodine-containing radiopaque agents.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, celecoxib) because the risk of sudden kidney failure and lactic acidosis may be increased
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