The below information on Avandia has been taken from official FDA sources, but we cannot guarantee it's accuracy. Please use this site for educational purposes only. This site does not replace a proper discussion with your doctor.

    Brand Name:Avandia
    Generic:Rosiglitazone Maleate
This drug was approved by the FDA in one form or another on:
1999-05-25 ,
This drug is made in one form or another by the following companies:
SB Pharmco
This drug is available in the following forms:
View the actual FDA approved label for this drug at the following links:

About Avandia

Avandia, in addition to diet and exercise, improves blood sugar control in adults with type 2 (non-insulin-dependent) diabetes. Avandia can be used alone or in combination with a sulfonylurea, metformin, or insulin. Avandia can also be used in addition to a sulfonylurea plus metformin when diet, exercise, and both agents are not enough to control blood sugar.

Precautions for Avandia

  • Avandia is in the same class of drugs as Rezulin, which has been associated with rare but serious liver injury, including liver failure leading to transplant or death. Because Avandia’s liver safety profile is not fully determined yet, your doctor will do blood tests that evaluate your liver before starting you on Avandia. These blood tests should be repeated every two months for the first year, then regularly after that.
  • Call your healthcare provider right away if you develop nausea, vomiting, stomach pain, a feeling of tiredness or having no energy, loss of appetite, dark urine, or jaundice (yellow coloring of eyes and skin). These may be symptoms of liver problems.
  • Patients who experience an unusually rapid increase in weight or retain fluid (edema) or who develop shortness of breath or other symptoms of heart failure while on Avandia should immediately report these symptoms to their healthcare provider.
  • Call your doctor if you develop visual symptoms, such as decreased vision or blurry vision, while taking Avandia. Some patients have developed macular edema (a swelling in the back of the eye) while taking Avandia. All patients with diabetes should have eye examinations regularly, no matter what medicine(s) they are taking for diabetes.
  • When taking Avandia with other oral diabetes medicines, there is a risk of your blood sugar becoming dangerously low. Ask your healthcare provider about symptoms of low blood sugar, conditions that make low blood sugar more likely, and what to do if you get it. Make sure to explain to family members.
  • If you are a woman who has not reached menopause but have not had menstrual periods, you may become pregnant unless you use an effective method of birth control. Avandia, like other drugs in this class, may cause insulin resistant women to start ovulating again.
  • Women should tell their doctor if they notice any changes in their monthly menstrual cycle.
  • During periods of stress on the body, such as fever, trauma, infection, or surgery, your medication requirements may change; contact your healthcare provider promptly.

Managing your diabetes should include diet control. Caloric restriction, weight loss as needed, and exercise are essential for the proper treatment of diabetes because they help improve insulin sensitivity and the effectiveness of drug therapy.

Side Effects of Avandia

  • cough or cold
  • headache
  • inflammation of the sinuses
  • back pain
  • swelling or fluid retention

Who Should Not Take Avandia

  • Do not use Avandia for type I diabetes (juvenile diabetes) or diabetic ketoacidosis.
  • If you have heart failure, fluid retention, or active liver disease your healthcare provider will evaluate you to decide if Avandia is right for you.
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Recent Forum Posts on Avandia

Wondering about Advandia

About 3 years ago I was on the drug Adandia fo 2 months. I became very weak and a lot of acheing in the muscles. Before I startd takeing it I was walking 3 to 4 mile a day with no problem. After my reaction to it I have tried everything to get my legs to do even a minamum amount of walking I have tried short spells longer ones everything I can think of to get the strength back in my legs. Have you ever had anyone with this problem before. And what would you suggest for a solution

Muscle weakness

My blood sugar has been well controlled with Avandia - however I have started to have fluid retention - especially in my feet and muscle weakness has gotten worse.

Death by Avandia

My husbands Dr. prescribed Avandia knowing that he suffered from heart failure. He swelled gradually and when his scrotum swelled it was an emergency which put him in the hospital for two weeks while they attempted to extract the fluid from all over his body. His heart monitor was almost flat lined yet they still administered and prescribed Avandia to him. He went home but had difficulty getting around. Then within less than two months he had a heart attack in the middle of the night. He was rushed to the emergency room by ambulance and was in and out of hospitals and nursing homes until his death eight months later. He was only 59. They continued to give him Avandia. He had some very unusual swelling of the arms and fluid would wheep from the pores in his arms. Don't take Avandia! It's a killer!


iam a type 2 dib. i was put on avandia because my back hurt all the time and my insides was burning up i started taking it and for about 3weeks i felt great but now it's doing the same.iam still on for now but guess after reading all about it ill try something else. thank you nicha.

Liver Problems

I am a Type 2 diabetic my Dr. had originaly had me on Avandamet 2mg/1000. I did well on this drug except for slight cramps in my legs. I had to stop taking it when the Gov. stopped production. My Dr. then put me on Avandia 4mg & Metformin 1000mg. After a week I had started to have a reaction to the Avandia ( hurt all over ,short breath, etc. ) so he took me off the Avandia & just had me take 1/2 the Metformin once every 12hr,s. The problem with this was that it did not control my sugar well enough(130 to 200), so he tried avandia again at alower dose 2mg which I cut in 1/2 to make 1mg once a day with the Metformin 500mg twice a day. After 4 days I am constipated ,have no energy ,& feel tired all time ,also I feel alittle dizzy at times & my kidneys hurt some. I can also feel my liver aching alittle so I stopped taking the Avandia & was wondering if I might need to stop taking the Metformin for awhile since it effects the liver. I am very glade that my inter voice urged me to cut the Avandia pills in 1/2 ,because I would be in much worse shape if I had not. I am wondering if there is a different Med. substute for the Avandia . And will my liver get better fairly quick?

No Subject

My Mother In-law started taking Avandia about 7 months ago and staring experiencing dizziness, fatigue, shortness of breath, excessive fluid retention, and painfull swelling in the upper legs and kness. She had fallen a few times(which I think could be related to the medication) and attributed the pain in the legs to that. After reading all these stories I am now convinced the problem is the Avandia. Instead of her doctor realizing the fluid retention and excessive weight gain he scheduled her to see an orthapedic sergeon for her knees. It's obvious her problem is far worse the worn cartlige in the knee. Thanks to everyone who wrote in, I now can give my mother in-law some testimonials from people who are experiencing the same side effects. When are these doctors going to take these claims serious!!!!


i started taking avandia and metformin 6 months ago and have gained 50 pounds... i watch what i eat and walk on a treadmill 45 minutes every day, still no weight loss. i am tempted to stop taking the avandia but i am afraid of my blood sugar skyrocketing again...it's a losing battle...


I've just began to take Avandia and wondered if anyone else is experiencing jumpiness around the heart more noticable in the early morning hours. I don't seem to notice it during the day. It seems to be the only side effect I've had and of course may not be the medicine at all.

Just looking for feedback . . .

avandia and weight gain

I have been on Avandia and Glucaphagae-also tenormen for blood pressure and I have had weight gain. I try everything to loose weight and I can not become successful. I am wondering what drugs I can take to replace these drugs so that I may successfully loose weight. It is so discouraging to constantly try with every diet know to man and still have little or no results at all.

Joint Pain

I have experienced EXTREME joint pain since I started taking Avandia 3 weeks ago. I'm to the point I'm almost in tears from walking from my car to inside my house. I've stopped taking it for 2 days now and hope the pain goes away soon.


I have gained weight since I began Avandia along with Glucophage and Lantus insulin. I was not sure what was causing the weight gain since I am dieting and exercising, I don't notice fluid retention though. I wonder if Avandia is the cause of my weight gain?

severe back pain

I have only been on Avandia for one week, however I now have such severe lower back pain that I can't even move, walk or sit without severe pain. No injury caused this, has anyone else had this experience? What did you do about it?

tired/ weight gain

I barley have my blood sugar under control, i have gained tons of weight and my feet and ankels are huge! I have low blood pressure to, not dangerouse but much lower than my average.


I Started taking Avandia about two weeks ago with mediformin and glypzide.
My had extreme joint pain in my legs that I could hardly walk. It brought my sugar down to 110, but I called my Dr. about the pain and he said to stop taking it. I did not take it this morning and hope the pain will go away soon.

Avandia swelling and weight gain

I have been taking Avandia now for about 3 and 1/2 months. It seemed to work fine at first but I noticed that I had started to gain weight. Now my feet and legs have been swelling real bad. I was going out walking every day but for the last month I have been unable to. My feet and legs are so swollen that I am unable to get my shoes on after I have been up for a couple of hours, and my feet hurt so badly. When I went to the doctor this week for my lab work and check up he was very concerned. He upped my lasix from 20 mg to 80 mg and told me to stop taking the Avandia. I hope that this will take care of the problem.

Weight Gain

I am a Type II diabetic. My Dr. prescribed Avandamet for me last September. It was effective in lowering my sugars; however, even though my eating habits had not changed (indeed, they became better, as I tried to eat less and more healthfully) I was shocked to see at my Dr. visit last week that I've gained 37 pounds! I feel terrible and bloated and my legs have ballooned to twice their size. None of my clothes fit and, despite my trying to diet, my weight is constantly going UP at each visit weigh-in!! When I questioned my doctor about it, he claimed he did not know about the side effect of the weight gain; however, the nurse took me aside and confirmed that this drug and also Avandia alone DOES cause weight gain! I demanded to be taken off the Avandamet immediately and am now on 2000 mg of Metformin daily. If I do not see any improvement I am sorely tempted to just quit the drugs altogether and try to lower the sugars with aggressive dieting and exercise alone. WHY ARE WE NOT BEING TOLD THE TRUTH?? On the one hand, we are nagged to lose weight and when we gain, we are not told why, or the subject is brushed under the rug. I was told by him, however, that insulin therapy does cause weight gain. I feel so disheartened and panicky that my weight is spiralling out of control by these treatments.


I am pre-diabetic. I have been controlling my glucose levels very well through proper diet and excerise. I am in perfect health other than the slightly high glucose levels. I have strong bones, no back problems, energetic, and at my perfect wieght. I went to my Doctor. She advised me to start on Advandia......after reading all these testimonials, I thankfully decided not to!!! Why would I mess myself up by taking this medication when I can do this naturally? Yes....it takes a lot....I mean, a lot of determination. According to the side effects and the comments......it is better than the alternative!!!!!
Serious complications are something I will strive to live without!

lower back pain

I have been put on Avandia 2mg to help control my blood sugar. I have been taking it for 7 days. I have experienced a little stiffness around my neck and shoulders, and lower back pain on my right side. My feet and ankles are a little tender, but not a lot of swelling. I called the doctor's office but my regular doctor was not there, so I received advice from another doctor. I asked if this medication affects the kidneys. He said no, it should not affect the kidneys. My regular doctor when he first prescribed this Avandia, I ask him are there any side affects, and he told me that there may be some swelling of the ankles, but he has not heard of this causing any serious side affect. I am due for another blood test in 3 weeks because he wants to see how my body reacts to the new medication.
I was taking crestor for my high cholestrol, and it affected my liver. I was only taking it for one month prescribed by another doctor. The took me off of it, and now I am taking Zetia, which I never seem to have any side affects. Advice, make sure to check to see what meds mix with which,


I have been taking Advandia for about 6 months and have also noticed modest weight gain. However, my biggest concern is the severe muscle weakness and pain in my right arm. All tests have confirmed no causes for this ailment. I also began Lipitor at the same time and know that Lipitor can cause muscle weakness. However I stopped taking that after two months and the weakness should have subsided. NO!! Has anyone else experienced these symptoms?


minutes after taking it I started flushing - heating throughout my body,
then pain in my stomach, it felt like the inside of my stomach was bubbling
and melting - burning and disolving, it must of removed - disolved the
mucous lining . I've had a CT Scan, Ultra sound and EGD. The EGD revealed gastritis my mucous lining did disolve!

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