The below information on Combunox has been taken from official FDA sources, but we cannot guarantee it's accuracy. Please use this site for educational purposes only. This site does not replace a proper discussion with your doctor.

    Brand Name:Combunox
    Generic:Ibuprofen, Oxycodone Hydrochloride
This drug was approved by the FDA in one form or another on:
2004-11-26 ,
This drug is made in one form or another by the following companies:
Forest Laboratories
This drug is available in the following forms:
View the actual FDA approved label for this drug at the following links:

About Combunox

Combunox is used for:

Treating moderate to severe pain over a short period of time (no more than 7 days).

Combunox is a narcotic and NSAID combination. The NSAID reduces the formation of prostaglandins that cause pain and inflammation. The narcotic works on the narcotic receptors in the brain to decrease pain.

Side Effects of Combunox

Possible side effects of Combunox :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

  • Anxiety;
  • constipation;
  • diarrhea;
  • dizziness;
  • drowsiness;
  • headache;
  • indigestion;
  • infection;
  • nausea;
  • nervousness;
  • sleeplessness;
  • stomach pain;
  • swelling;
  • tiredness;
  • upset stomach;
  • vomiting;
  • weakness.
Seek medical attention right away if any of these SEVERE side effects occur:
  • Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue);
  • black, tarry, or bloody stools;
  • blurred vision or other eye problems;
  • chest pain;
  • dark urine;
  • fainting;
  • fast or irregular heartbeat;
  • fever;
  • increased or decreased urination;
  • irregular or difficult breathing;
  • mental or mood changes;
  • red, swollen, blistered, or peeling skin;
  • severe or persistent dizziness;
  • severe or persistent stomach pain;
  • stiff neck;
  • swelling of the arms or legs;
  • unusual tiredness or weakness;
  • unusual weight gain;
  • vomit that looks like coffee grounds;
  • yellowing of the skin or eyes.

Who Should Not Take Combunox

Do NOT use Combunox if:

  • you are allergic to any ingredient in Combunox or any other codeine- or morphine-related medicine (eg, codeine)
  • you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, hoarseness, dizziness) to aspirin or an NSAID (eg, ibuprofen, naproxen, celecoxib)
  • you have had asthma or nasal growths after taking aspirin
  • you have difficult or irregular breathing, active or severe asthma, high levels of carbon dioxide in the blood, severe bowel problems (eg, lack of muscle movement, diarrhea due to poisoning or antibiotic use), or severe kidney disease
  • you are taking sodium oxybate (GHB) or have taken a monoamine oxidase (MAO) inhibitor (eg, phenelzine) within the past 14 days
  • you are having or have recently had heart bypass surgery

Contact your doctor or health care provider right away if any of these apply to you.

Interactions with Combunox

Some MEDICINES MAY INTERACT with Combunox . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticholinergics (eg, benztropine), cyclosporine, MAO inhibitors (eg, phenelzine), probenecid, selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), or tricyclic antidepressants (eg, amitriptyline) because side effects of Combunox may be increased
  • Antihistamines (eg, diphenhydramine), barbiturate anesthetics (eg, thiopental), barbiturates (eg, phenobarbital), cimetidine, narcotic pain medicine (eg, codeine), phenothiazines (eg, chlorpromazine), sodium oxybate (GHB), or tranquilizers because the risk of excessive drowsiness or severe breathing problems may be increased
  • Agonist/antagonist analgesics (eg, pentazocine) or naltrexone because the effectiveness of Combunox may be decreased
  • Lithium, methotrexate, or neuromuscular blockers (eg, pancuronium) because side effects may be increased by Combunox
  • Anticoagulants (eg, warfarin), corticosteroids (eg, prednisone), heparin, quinolone antibiotics (eg, ciprofloxacin), or salicylates (eg, aspirin) because the risk of bleeding or seizures may be increased
  • Angiotensin-converting enzyme (ACE) inhibitors (eg, captopril), loop diuretics (eg, furosemide), or thiazide diuretics (eg, hydrochlorothiazide) because the effectiveness may be decreased by Combunox
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