The below information on Comtan has been taken from official FDA sources, but we cannot guarantee it's accuracy. Please use this site for educational purposes only. This site does not replace a proper discussion with your doctor.

    Brand Name:Comtan
This drug was approved by the FDA in one form or another on:
1999-10-19 ,
This drug is made in one form or another by the following companies:
Orion Corporation
This drug is available in the following forms:
View the actual FDA approved label for this drug at the following links:

About Comtan

Comtan is used together with carbidopa/ levodopa to treat people with Parkinson’s disease that experience the signs and symptoms of end-of-dose "wearing-off".

Comtan’s effectiveness has not been proven in people with Parkinson’s disease that do not experience end-of-dose "wearing-off".

Precautions for Comtan

  • Comtan should be used with caution in patients with liver problems.
  • Do not stop taking Comtan without first discussing it with your doctor.
  • Do not drive a car or operate heavy machinery until you know how you will react to Comtan.
  • Be especially careful when taking other sleep-inducing drugs while using Comtan

Side Effects of Comtan

Some of the side effects listed below may not appear for up to twelve weeks.

  • Abnormal jerky movements
  • Nausea
  • Discolored (brownish orange) urine
  • Diarrhea
  • Abdominal pain
  • Dizziness or fainting especially upon quickly standing or going from a laying down to an upright position
  • Confusion
  • Sweating

Individuals treated with Comtan should tell their health care provider right away if they develop any of the following symptoms:

  • Severe diarrhea
  • Hallucinations
  • Muscle pain or prolonged rigidity
  • High fever

Interactions with Comtan

  • Because certain other medications can interact with Comtan, review all medications that you are taking with your health care provider, including those that you take without a prescription.
  • Check with your health care provider to make sure that you are not taking certain types of monoamine oxidase (MAO) inhibitors.
  • Tell your health care provider if you are trying to become pregnant, are pregnant, or are breast-feeding.
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Recent Forum Posts on Comtan

aches in my feet!

Until today I was taking Sinemet 25/100 4 times daily and used Comtan at the same time. As of today the doctor changed my meds to just Sinemet25/250 2 times a day. Now I walk better but my feet ache really bad all the time and the doctor can't explain it. I wonder if its caused by the new Sinemet or is caused by stopping the Comtan abruptly. Please reply A.S.A.P. Thanks

No Subject

c200 helps along with the requip (3/day)and c/l 25/250

it seems that i cant go beyond three hrs.

i take the c200 w/ c/l 5 times /day

come on get a cure. which one will prevail?

1. tristem

2. u of mn,(supposedly looking for test subjects)

3. the koreans who cured, yes, cured their lab rodents of pd

are stem cells the answer? i dont like the invasiveness of dbs. on this aspect tristem seems to be far ahead of the pack. only question is, will it work?


How long does it take for Comtan to take effect? So far (after 4 days), this drug has done absolutely nothing. My Mother takes this along with Sinemet (50/200). So far, her symptoms are MUCH, MUCH worse AFTER taking this new drug. All she does is vomit all day long, pee on the floor and act totally confused. What gives?

No Subject

my mother has parkinsons,and is having a very difficult time she is taking sidment 3 times a day along with comtan but doesn't seem to be doing any good having panic attacks 2 sometimes 3 times a day ,no one can seem to figure this out can't find anything to stop this .what a life she has it is just terrible for my father who is always with her ,he is stressed out all the time she is in a home and because he spend alot of time there the staff doesn't even bother to check on her he has full care of her while he is there .iwas wondering if anyone knows anything about panic attacks

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