The below information on Hepsera has been taken from official FDA sources, but we cannot guarantee it's accuracy. Please use this site for educational purposes only. This site does not replace a proper discussion with your doctor.

    Brand Name:Hepsera
    Generic:Adefovir Dipivoxil
This drug was approved by the FDA in one form or another on:
2002-09-20 ,
This drug is made in one form or another by the following companies:
Gilead Sciences, Inc.
This drug is available in the following forms:
View the actual FDA approved label for this drug at the following links:

About Hepsera

Hepsera is an antiviral medicine used to treat adults with chronic infections with active hepatitis B virus who have:

  • active hepatitis B virus in their blood
  • high levels of liver enzymes in their blood
  • liver damage that is seen on a liver biopsy

Precautions for Hepsera

  • It is very important to take Hepsera exactly as prescribed by your health care provider for the entire time that you are being treated. It is especially important not to stop taking Hepsera without first talking to your health care provider or else your liver disease may get worse.
  • Since Hepsera does not stop you from passing hepatitis B to others, it is important to avoid activities that can spread hepatitis B virus. This includes:
    • do not share needles of any kind
    • do not share razors, toothbrushes, or other items that may carry blood or bodily fluids
    • do not have unprotected sex, and always practice “safe sex” by using condoms and dental dams

Side Effects of Hepsera

  • Hepsera can cause a worse or very serious hepatitis in some people when they stop taking Hepsera. This usually happens within 12 weeks after stopping. You will need to have regular blood tests to check for liver function and hepatitis B virus levels if you stop taking Hepsera.
  • Hepsera can cause liver enlargement and damage to the liver. Some of the warning signs of liver damage can be yellowing of the skin or eyes, dark urine, light-colored stools, nausea, lower stomach pain, or loss of interest in eating for several days.
  • Hepsera may cause kidney damage. This usually happens in people that already have a kidney problem, but it can happen to anyone taking Hepsera.
  • If you get or have HIV that isn't being treated with medicines, Hepsera may increase the chances your HIV infection cannot be helped with usual HIV medicines. You should get an HIV test before you start taking Hepsera and anytime after that when there is a chance you were exposed to HIV.
  • Hepsera can cause a serious condition called lactic acidosis (build up of lactic acid in the body). Lactic acidosis is a medical emergency and must be treated in the hospital. Some of the warning signs of lactic acidosis can be weakness, tiredness, unusual muscle pain, trouble breathing, stomach pain with nausea and vomiting, cold feelings in your arms or legs, dizziness, or irregular heartbeat.

In addition to the serious side effects listed above, the most common side effects of Hepsera are:

  • weakness
  • headache
  • stomach pain
  • nausea

Who Should Not Take Hepsera

Do not take Hepsera if you are allergic to any of the ingredients in Hepsera.

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Recent Forum Posts on Hepsera

No Subject

I started hepsera Sept. 25. I am a little tired, and my legs hurt.
Other wise I feel good.
I will be glad to keep you informed. RoyBoy!

started hepsera

I started hepsera Sept 22. I feel tired and belly full.
I will glad to keep you informed. Peter


I started taking it 4 months ago. Now I really feel very dizzy all the time and tired. I am affraid to stop taking it because it can worsen my case. I have not been feeling sexual at all, not sure if that is a side effect of the medication.

No Subject

Been using Hepsera for about five months now. Having some of the side effects. Body is having a strange odor, not sure if it is the liver malfunctioning, or if the medication is coming through my pours. Have seen any other comments regarding this.

No Subject

I was in the initial studies and after an initial scare (had a liver flare a couple of months into the study) my enzymes have been normal for about four years. My last visit to the physician conducting the trial showed that I have developed the surface antibody to the virus. He advised me to continue the drug and follow up with my primary care physician to see it it sustained. If it did after a year, we would try going of the medication to see what happens. Wonderful drug.

No Subject

I have been taking Hepsera for 10 months. I have no side effects. No complaints other than taste. Reading up on this because I was on Lamivudine and went to the new drug and my viral level elevated by 100,000 for the last 6 months. Just looking to see if this is normal.

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