The below information on Increlex has been taken from official FDA sources, but we cannot guarantee it's accuracy. Please use this site for educational purposes only. This site does not replace a proper discussion with your doctor.

    Brand Name:Increlex
    Generic:Mecasermin [recombitant DNA origin]
This drug was approved by the FDA in one form or another on:
2005-08-30 ,
This drug is made in one form or another by the following companies:
This drug is available in the following forms:
View the actual FDA approved label for this drug at the following links:

About Increlex

Increlex is an injectable prescription medicine used to treat children who are very short for their age because their bodies do not make enough insulin-like growth factor-1 (IGF-1). IGF-1 should not be used instead of growth hormone.

Increlex has not been studied in children under 2 years of age.

Side Effects of Increlex

Increlex may cause the following side effects, which can be serious:

  • Low blood sugar (hypoglycemia). Increlex may lower blood sugar levels like insulin. It is important to only give your child Increlex within 20 minutes right before or within 20 minutes right after a snack or meal to reduce the chances of low blood sugar. Do not give your child Increlex if your child is sick or cannot eat. Signs of low blood sugar are:
    • dizziness
    • tiredness
    • restlessness
    • hunger
    • irritability
    • trouble concentrating
    • sweating
    • nausea
    • fast or irregular heartbeat

Severe low blood sugar may cause unconsciousness, seizures or death. Your child should avoid participating in high risk activities (such as driving) within 2 to 3 hours after Increlex injection, especially at the beginning of Increlex treatment.

Before beginning treatment with Increlex, your child’s healthcare professional should explain to you the symptoms of low blood sugar and how to treat it.

  • Enlarged Tonsils. Increlex may enlarge your child’s tonsils. Some signs of tonsils that have increased in size include: snoring, difficulty breathing or swallowing, sleep apnea (a condition where breathing stops briefly during sleep), or fluid in the middle-ear. Your child’s healthcare professional should do regular exams to check your child’s tonsils.
  • Increased pressure in the brain (intracranial hypertension). Increlex, like growth hormone, can sometimes cause a temporary increase in pressure within the brain. The symptoms of intracranial hypertension can include headache and nausea with vomiting. Tell your child’s healthcare provider if your child has a headache with vomiting.
  • A bone problem called slipped capital femoral epiphysis. This happens when the top of the upper leg (femur) slips apart. Get medical attention for your child right away if your child develops a limp or has hip or knee pain.
  • Worsened scoliosis (caused by rapid growth). If your child has scoliosis, your child will need to be checked often for an increase in the curve of the spine.
  • Allergic reactions. Your child may have a mild or serious allergic reaction with Increlex. Call your child’s healthcare professional right away if your child gets a rash or hives. Get medical help immediately if your child has trouble breathing or goes into shock.

Increlex can cause reactions at the injection site including:

  • loss of fat
  • increase of fat
  • pain, redness or bruising

Who Should Not Take Increlex

Your child should not be treated with Increlex if your child:

  • has finished growing (the bone growth plates are closed)
  • has cancer
  • has other causes of growth failure
  • is allergic to mecasermin or any of the inactive ingredients in Increlex.

Your child should never receive Increlex through a vein.

Interactions with Increlex

Tell your child’s healthcare professional about all the medicines your child takes including prescription and non-prescription medicines, vitamins, and herbal supplements.

Especially tell your child’s healthcare professional if your child takes insulin or other anti-diabetes medicines.

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Recent Forum Posts on Increlex

Increlex and high BG

My son has been on Increlex for three weeks and his BG continued to rise up to 350 one day and started in the 80-90's and now never below 120 to 230's. I clean his finger with an alcohol pad everytime I check his BG. His Dr. doesn't think it could be the Increlex but we stopped the Increlex 4 days ago and his BG is back down to the 90's to low 100's at all times. It seems it can only be the Increlex but I can't find any info. on it causing high BG only lower???

No Subject

My son has been on Increlex for 2 weeks, I have noticed his nose is growing noticeably larger, is this a common side effect?

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