Iplex

The below information on Iplex has been taken from official FDA sources, but we cannot guarantee it's accuracy. Please use this site for educational purposes only. This site does not replace a proper discussion with your doctor.


    Brand Name:Iplex
    Generic:Mecasermin Rinfabate [recombitant DNA origin]
    Availability:Prescription
This drug was approved by the FDA in one form or another on:
2005-12-12 ,
This drug is made in one form or another by the following companies:
Insmed Incorporated
This drug is available in the following forms:
Injectables
View the actual FDA approved label for this drug at the following links:
http://www.fda.gov/cder/foi/label/2007/021884s001lbl.pdf

About Iplex

IPLEX is an injectable prescription medicine that contains man-made insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3). IPLEX is used to treat children with severe primary IGF-1 deficiency. Children with severe primary IGF-1 deficiency are very short for their age because their bodies do not make enough IGF-1.

IPLEX should not be used in place of growth hormone. IPLEX is not for other causes of growth failure. IPLEX is not for children less than 3 years old or adults with primary IGF-1 deficiency.

Side Effects of Iplex

  • Low blood sugar (hypoglycemia). IPLEX may lower your child’s blood sugar levels the way insulin does. Do not give your child IPLEX if your child has signs of low blood sugar which include dizziness, headache, tiredness, restlessness, hunger, irritability, trouble concentrating, sweating, nausea, or fast or irregular heartbeat.
  • Severe low blood sugar may cause unconsciousness, convulsions, or death. Your child should not do risky activities until the healthcare professional has found the right dose for your child. Before beginning treatment with IPLEX, your child’s healthcare professional should explain to you the symptoms of low blood sugar and how to treat it.
  • Enlarged tonsils. IPLEX may enlarge your child’s tonsils. Some signs of enlarged tonsils are snoring, problems breathing or swallowing, earaches, problems hearing, and breathing problems during sleep (sleep apnea, which can also cause excessive daytime sleepiness). Call your child’s healthcare professional if your child gets any of these symptoms. Your healthcare professional should do regular exams to check your child’s tonsils.
  • Increased pressure in the brain (intracranial hypertension). Signs of increased pressure in the brain include headache, nausea, vomiting, and vision problems. Call your child’s healthcare professional if your child has these symptoms.
  • A hip bone problem called slipped capital femoral epiphysis. This happens when the upper end of the leg bone (femur) slips apart. Get medical attention for your child right away if your child develops a limp, or has hip or knee pain.
  • Worsened curve of the spine (scoliosis). If your child has scoliosis, your child will need to be checked regularly for an increase in the curve of the spine.
  • Allergic reactions. Your child may have a mild or serious allergic reaction to IPLEX. Call your child’s healthcare professional right away if your child gets a rash or hives. Get medical help right away if your child has trouble breathing or goes into shock.
  • Reactions at the injection site including redness, pain, increase of fat, lumps under the skin, or slight hair growth.

Who Should Not Take Iplex

Your child should not take IPLEX if your child:

  • has finished growing (bone growth plates are closed)
  • has cancer
  • is allergic to mecasermin rinfabate or any of the inactive ingredients in IPLEX.
  • Never inject IPLEX into a vein.

Interactions with Iplex

IPLEX and certain other medicines can interact with each other. Tell your healthcare professional about all the medicines your child takes including prescription and non-prescription medicines, vitamins, and herbal supplements. Know the medicines your child takes. Keep a list of them with you to show your child’s healthcare professional.

It is especially important to tell your child’s healthcare professional if your child takes insulin or other medicine s for diabetes. A dose change may be needed for these medicines.

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