Mylotarg

The below information on Mylotarg has been taken from official FDA sources, but we cannot guarantee it's accuracy. Please use this site for educational purposes only. This site does not replace a proper discussion with your doctor.


    Brand Name:Mylotarg
    Generic:Gemtuzumab Ozogamicin
    Availability:Prescription
This drug was approved by the FDA in one form or another on:
2000-05-17 ,
This drug is made in one form or another by the following companies:
Wyeth Ayerst
This drug is available in the following forms:
Intravenous Injections
View the actual FDA approved label for this drug at the following links:
http://www.fda.gov/cder/foi/label/2006/021174s020lbl.pdf

About Mylotarg

Mylotarg is used to treat a form of bone marrow cancer (CD33 positive acute myeloid leukemia) in patients who are:

  • experiencing a return of the disease after the first treatment
  • 60 years of age or older, and
  • not considered able to take standard leukemia chemotherapy.

The safety and effectiveness of Mylotarg in patients with poor performance status and organ dysfunction is not known and has not been tested. In addition, the effectiveness of Mylotarg in improving symptoms, keeping the disease from getting worse, or helping patients live longer compared with standard treatments is not known.

Side Effects of Mylotarg

Common side effects include:

  • decrease in bone marrow production (see Special Warnings)
  • low red blood cell counts (anemia)
  • low blood platelets
  • infection
  • bleeding
  • transfusions
  • swelling of the membrane inside the mouth
  • liver problems
  • rash

If the following side effects occur, they will be soon after treatment with Mylotarg. Other medicines can be prescribed to improve these conditions:

  • chills
  • fever
  • nausea
  • vomiting
  • headache
  • changes in blood pressure
  • low levels of oxygen in the body

Who Should Not Take Mylotarg

When large numbers of leukemic cancer cells are being destroyed quickly, you may experience side effects which may cause pain in the joints (gout) or even kidney problems.

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Recent Forum Posts on Mylotarg

Mylotarg

My mother received Mylotarg for treatment of acute mylogenous lukemia. She is 77 yrs. old. She has been in complete remission for 9 mos. until now. She has had another bone marrow test done and we are awaiting the results due 7-10 days from now. She has below normal platelets, red cells and is borderline on her WBC. She's bruising, is tired, anemic, and has had minor diharreha. She had 2 chemotherapy treatments prior to the Mylotarg. The Mylotarg was what did the trick and she took it pretty well. At the time her bone marrow showed 65% cancer cells. She took only one treatment of Mylotarg as she felt that was enough at the time. We knew the protocol was 2 treatments, the second to be given 2 weeks after the first. Now since the cancer seems to be back (won't know for sure until the bone marrow test results)maybe the second treatment 2 weeks after the first would have been wise to take? Also, her symptoms appear to be as described re: low red blood cells (anemia), platelets, which are side effects of Mylotarg....please comment on my comments if you will and advise if you can. Thank you


Side Effects of Mylotarg

My Mother is 68 and has A.M.L. She is having Cytarabine over 4 sessions and also trials for Mylotarg. She has just received her second dose of Mylotarg which is administered via one injection on one visit. She hasnt had feedback yet, will be having bone marrow taken in 10 days to assess this.
I am concerned about the horrific side effects of the Mylotarg. She has the drug then is observed for 4 hours. The first observation showed nothing yet, one hour following her getting home she suffered extreme nausea, vomiting, fever, hot and cold temperatures in the 40's and shaking. She managed to get warm and went to bed to 'sleep it off' and was okay in the morning, albeit knocked about by the reaction.
The second dose last week however gave severe and distressing reaction the same time scale too - only the clinic where it was given had chosen to send her home earlier as she seemed to be stronger in herself.
When she got home - 2 hours after the injection of Mylotarg - she suffered almost seizure like fits of uncontrolled shaking, vomiting of bright yellow sick and had temp of 40+. I am not trained as a nurse and she lives 30+ miles from hospital. I had to get the ambulance there. They gave her anti nausea tablets and got her temp down by removing her bedding a bit.

She had not been warned of these 'fits'or seizures and had been advised to take the anti nausea drugs "when" she felt sick, not BEFORE! to prevent sickness!!
She is now terrified to continue with the whole thing - it was distressing, painful and to date, we dont know if it is working.

I would be very grateful to talk to someone about this please - anything and any voice would be welcomed.

Kind wishes, Mary


mylotarg

I would like to know from wich country mylotarg comes?
my father (75) will be threated tomorrow with mylotarg
I would like to know the origine of mylotarg and who found this new therapy?
thanks, Tine


cost price Mylotarg

Please give detail how alone Mylotarg injection will help edlterly person requiring 400ml plalate every week now in coma having AML? Hoe Long?
Thank you


liver failure

After my younger brother's treatment with Mylotarg, he experienced extreme joint paint and liver failure within a few days. He died a day after liver failure. We did have a glimmer of hope for a couple of days which I am grateful for. I wish he could have had it before a last option.
Maybe he would be alive today. He was suffering from AML.


Taking mylotarg

My friend is in 60s and is where they cannot give anymore of the
common chemo, and wants him to get this, he fears that it can
cause more damage to his uncancerous cellls. I tried to say that
this stuff only homes in on cancer cells and attaches to this.
He wonders why all the side affects, my response to this is that
anytime they lower your immune system to take out poisons and this
is a toxin then your going to experience these side affects, plus
getting the bad effects of the med out too. I see stats here that
tell how bad it worked..but these were both not positive...are there
any people that survived this and how long....please reply.


Adam

Hello

My son adam will be taking the mylotarg tom on the 19th here in Vancouver childrens hosptial he is the first child here to try this drug. He was diagnosed with AML in aug/02 was in remission and then june/03 relapsed to 72% and then in Sept he was still 20% and then they gave adam three chemo's but in Nov bone marrow bio it was 60% they then put my son on Pallitive care and then my Doctor told us about this drug and he said there may be liver failure and only a 15 to 20% chance of getting into remission. With adam's relapsed could this drug work to get him into remission and into a bone marrow transplant.
thank you
Donna (his mom)


AML

My brother has a relapse of AML after the chimo, he cannot endeure another bout of the treatment. The oncologist has recommended Mylotrag which is not readily available where he lives in Kusdiatan, Iran. Does anyone know how to procucre the medicine and ship overseas.

Thanks,
Shawn


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