Noxafil

The below information on Noxafil has been taken from official FDA sources, but we cannot guarantee it's accuracy. Please use this site for educational purposes only. This site does not replace a proper discussion with your doctor.


    Brand Name:Noxafil
    Generic:Posaconazole
    Availability:Prescription
This drug was approved by the FDA in one form or another on:
2006-09-15 ,
This drug is made in one form or another by the following companies:
Schering-Plough
This drug is available in the following forms:
Oral Suspensions
View the actual FDA approved label for this drug at the following links:
http://www.fda.gov/cder/foi/label/2006/022003lbl.pdf

About Noxafil

Noxafil is a prescription medicine used in patients, 13 years and older, with weak immune systems to prevent serious Candida and Aspergillus fungal infections. Patients who are at risk of developing these serious fungal infections include those:

  • with advanced HIV disease
  • who have had stem cell transplants and have a disease called graft versus host disease (GVHD),
  • who are undergoing chemotherapy for cancer treatment

Noxafil is also used to treat fungal infections in the mouth area (known as “thrush”) caused by fungi called Candida.

Noxafil has not been studied in children under the age of 13.

Side Effects of Noxafil

Noxafil can cause serious problems such as:

  • drug interactions. Noxafil can interact with many medicines and cause serious side effects including death. Sometimes the doses of your other medicines may need to be lowered or you may need to be checked more often. Know the medicines you take. Keep a list of them to show your healthcare professional.
  • allergic reaction.You may have an allergic reaction to posaconazole or the other ingredients in Noxafil. Tell your healthcare professional if you ever had an allergic reaction to another antifungal medicine Call your healthcare professional right away if you have any of the following symptoms of an allergic reaction:
    • rash
    • hives
    • redness of the skin
    • itching
    • shortness of breath
    • low blood pressure
  • liver damage.Noxafil may cause damage to the liver. The risk of liver damage may be worsened when Noxafil is given to patients with serious medical conditions who are also taking several other medicines. Your healthcare professional may do blood tests to monitor your liver function at the start of treatment with Noxafil and during treatment with Noxafil.
  • irregular heart beat. Noxafil may cause dangerous problems with your heart rhythm. Call your healthcare professional right away if you:
    • have fainted or lost consciousness
    • feel a change in the way your heart normally beats (palpitations)
  • Some common side effects that may occur with Noxafil include:
    • liver problems
    • nausea or vomiting
    • diarrhea
    • fever
    • headache
    • low blood potassium
    • low white blood cell counts

Who Should Not Take Noxafil

You should not take Noxafil if you:

  • take the following medicines:
  • migraine medicines called “ergot alkaloids”
  • terfenadine
  • astemizole
  • cisapride
  • pimozide
  • halofantrine
  • quinidine

If you are not sure about your medicines, talk to your doctor.

  • are allergic to anything in Noxafil
  • have an irregular heart rate
  • cannot take a full meal or nutritional supplement

Interactions with Noxafil

Noxafil and many other medicines can interact with each other, sometimes causing serious side effects. Tell your healthcare professional about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Know the medicines you take. Keep a list of them to show your healthcare professional. Do not take any new medicine while taking Noxafil unless your healthcare professional has told you it is okay.

Especially tell your healthcare professional if you take:

  • cyclosporine (Neoral), tacrolimus (Prograf), or sirolimus (Rapamune)
  • migraine or antispasmodic medications referred to as “ergot alkaloids.”
  • certain chemotherapy medications referred to as “vinca alkaloids”
  • cimetidine
  • rifabutin
  • phenytoin
  • halofantrine
  • astemizole
  • midazolam
  • quinidine
  • pimozide
  • cholesterol lowering agents referred to as “statins.”
  • certain blood pressure medications referred to calcium channel blockers

This is NOT a complete list. These medicines may affect how Noxafil works, or Noxafil may affect how these medicines work. Bring a list of all your medicines with you to show your healthcare professional.

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