The below information on Phenergan has been taken from official FDA sources, but we cannot guarantee it's accuracy. Please use this site for educational purposes only. This site does not replace a proper discussion with your doctor.

    Brand Name:Phenergan
    Generic:Promethazine Hydrochloride
This drug was approved by the FDA in one form or another on:
1951-03-29 ,
This drug is made in one form or another by the following companies:
Wyeth Pharmaceuticals, Inc.
This drug is available in the following forms:
View the actual FDA approved label for this drug at the following links:

About Phenergan

Promethazine is an antihistamine which can be taken by mouth as a tablet or syrup, rectally as a suppository, or by injection. It can be used for:

  • “hay fever,” or, a stuffy runny nose from allergy
  • watery, itchy eyes due to inhaled allergies and foods
  • mild allergic skin reactions with itching and swelling
  • allergic reactions to blood or plasma
  • dermographism, a form of hives known as “skin writing”
  • serious allergic reactions along with epinephrine and other treatments
  • sedation before or after surgery, or during childbirth
  • prevention and control of nausea and vomiting after surgery
  • along with meperidine (demerol) or other pain medicines
  • sedation, relief of anxiety, and production of light sleep from which the patient can be easily aroused
  • treatment and prevention of motion sickness

Side Effects of Phenergan

  • Severe drowsiness and reduced mental alertness. Promethazine may cause drowsiness which may impair your ability to ride a bike, drive a car, or operate machinery. This may be worsened if taken with alcohol or other drugs that also cause central nervous system (CNS) slowing such as sedatives, pain medicines, tranquilizers or certain drugs for depression.
  • Serious breathing problems. Promethazine should not be used in patients with poor lung function such as chronic obstructive lung disease or breathing problems while sleeping (sleep apnea).
  • Increased risk of seizures. Promethazine should be used with caution in patients with seizures or who are on other medicines which may also increase the risk of seizures.
  • Bone-marrow problems and blood cell production. Promethazine should not be used in patients with bone-marrow problems or used with other drugs that affect the bone marrow’s production of blood cells.
  • Neuroleptic malignant syndrome. This potentially deadly syndrome includes symptoms such as fever, muscle rigidity, mental changes, changes in pulse or blood pressure, fast heartbeat, increased sweating or irregular heart rhythm.
  • The most common side effects are drowsiness, changes in blood pressure, skin reactions, blood cell changes and breathing problems. Increased excitability or abnormal movements may occur after one dose of promethazine. If they do, consult your doctor about using another medicine.

Who Should Not Take Phenergan

p>Promethazine should not be given to:

  • children under two years of age
  • patients who are unconscious
  • patients who are allergic to promethazine, any of the ingredients in promethazine, or to other phenothiazines
  • patients with lung symptoms including asthma
  • children who are vomiting unless the vomiting is prolonged and there is a known cause

Interactions with Phenergan

Promethazine and certain other medicines can interact with each other. Tell your healthcare professional about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Some medicines may affect how promethazine works or promethazine may affect how your other medicines work. Know the medicines you take. Keep a list of them with you to show your healthcare professional.

Especially tell your healthcare professional if you take:

  • medicines that affect your brain such as anti-anxiety medicine, sleeping pills, pain medicines, sedatives, narcotics, antidepressants or tranquilizers
  • epinephrine
  • a monoamine oxidase inhibitor (MAOI) which is used to treat depression or other mental disorders
  • medicines called anticholinergics
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Recent Forum Posts on Phenergan

No Subject

Keep this Meds in my frig, just in case. So many of my medicines cause nausea, that this is a god=send! THANKS!

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