Prezista

The below information on Prezista has been taken from official FDA sources, but we cannot guarantee it's accuracy. Please use this site for educational purposes only. This site does not replace a proper discussion with your doctor.


    Brand Name:Prezista
    Generic:Darunavir Ethanolate
    Availability:Prescription
This drug was approved by the FDA in one form or another on:
2006-06-23 ,
This drug is made in one form or another by the following companies:
Tibotec
This drug is available in the following forms:
Tablets
View the actual FDA approved label for this drug at the following links:
http://www.fda.gov/cder/foi/label/2006/021976s001lbl.pdf

About Prezista

Prezista is an oral tablet used for the treatment of HIV (Human Immunodeficiency Virus) infection in adults. HIV is the virus that causes AIDS (Acquired Immune Deficiency Syndrome). Prezista is a type of anti-HIV drug called a protease inhibitor.

Prezista does not cure HIV infection or AIDS. At present, there is no cure for HIV infection. People taking Prezista may still develop infections or other conditions associated with HIV infection. Because of this, it is very important for you to remain under the care of a doctor. Although Prezista is not a cure for HIV or AIDS, Prezista can help reduce your risks of getting illnesses associated with HIV infection (AIDS and opportunistic infection) and eventually dying from these conditions.

Prezista does not reduce the risk of passing HIV to others through sexual contact, sharing needles, or being exposed to your blood.

When used with other anti-HIV medicines, Prezista may reduce the amount of HIV in your blood and increase your CD4 cell count. Reducing the amount of HIV and increasing the CD4 cell count may improve your immune system and, thus, reduce the risk of death or infections that can happen when your immune system is weak.

Side Effects of Prezista

  • Mild to moderate rash has been reported in 7% of subjects receiving Prezista. In some patients, Prezista has been reported to cause a severe or life-threatening rash. Contact your healthcare provider if you develop a rash.
  • High blood sugar (hyperglycemia) and diabetes. This can happen in patients taking Prezista or other protease inhibitor medicines. Some patients have diabetes before starting treatment with Prezista which gets worse. Some patients get diabetes during treatment with Prezista. Some patients will need changes in their diabetes medicine. Some patients may need new diabetes medicine.
  • Increased bleeding in patients with hemophilia. This may happen in patients taking Prezista as it has been reported with other protease inhibitor medicines.
  • Changes in body fat. These changes can happen in patients taking anti-HIV medicines. The changes may include an increased amount of fat in the upper back and neck, breast, and around the back, chest, and stomach area. Loss of fat from the legs, arms, and face may also happen.
  • Immune reconstitution syndrome. In some patients with advanced HIV infection (AIDS) and a history of opportunistic infection, signs and symptoms of inflammation from previous infections may occur soon after anti-HIV treatment is started. It is believed that these symptoms are due to an improvement in the body’s immune response, enabling the body to fight infections that may have been present with no obvious symptoms.
  • The most common side effects that may occur with Prezista include: diarrhea, nausea, headache, and common cold.

Who Should Not Take Prezista

Do not take Prezista if you:

  • are allergic to darunavir or any of the other ingredients in Prezista
  • are allergic to ritonavir (Norvir)
  • take any of the following types of medicines because you could experience serious side effects:
  • antihistamines (to treat allergy symptoms)
  • ergot derivatives (to treat migraine and headaches)
  • gastrointestinal motility agents (to treat some digestive conditions)
  • neuroleptics (to treat psychiatric conditions)
  • sedative/hypnotics (to treat trouble with sleeping and/or anxiety)

Interactions with Prezista

Prezista and certain other medicines can interact with each other. Tell your healthcare professional about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements, including St. John’s wort. Sometimes serious side effects will happen if Prezista is taken with certain other medicines. Know the medicines you take. Keep a list of them with you to show your healthcare professional.

Especially tell your healthcare professional if you take:

  • any of the medicines listed in “Who Should Not Take Prezista”
  • estrogen-based contraceptives. You must take additional precautions for birth control such as a condom.
  • other anti-HIV medicines. Prezista can be combined with some other anti-HIV medicines while other combinations are not recommended.
  • antiarrhythmics (to treat abnormal heart rhythms)
  • anticoagulants (to prevent the clotting of red blood cells called platelets)
  • anticonvulsants (to treat epilepsy and prevent seizures)
  • antidepressants
  • anti-infectives (to treat bacterial infections)
  • antifungals (to treat fungal infections)
  • antimycobacterials (to treat bacterial infections)
  • calcium channel blockers (to treat heart disease)
  • corticosteroids (to treat inflammation or asthma)
  • HMG-CoA reductase inhibitors (to lower cholesterol levels)
  • immunosuppressants (to prevent organ transplant rejection)
  • narcotic analgesics
  • PDE-5 inhibitors (to treat erectile dysfunction)
  • selective serotonin reuptake inhibitors (SSRIs) (to treat depression, anxiety, or panic disorder)
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