The below information on Ranexa has been taken from official FDA sources, but we cannot guarantee it's accuracy. Please use this site for educational purposes only. This site does not replace a proper discussion with your doctor.

    Brand Name:Ranexa
This drug was approved by the FDA in one form or another on:
2006-01-27 ,
This drug is made in one form or another by the following companies:
CV Therapeutics
This drug is available in the following forms:
Tablets, Extended Release
View the actual FDA approved label for this drug at the following links:

About Ranexa

Ranexa is used to treat adults with chronic chest pain (angina). Ranexa can cause a serious heart beat problem called QT prolongation. Because of this problem, Ranexa should only be used after other angina medicines have not relieved chest pain symptoms. Ranexa should be used with amlodipine (Norvasc), beta blocker medicines, or nitrate medicines. Ranexa does not relieve sudden chest pain.

Chronic chest pain (angina) is caused by not enough blood flow to the heart. Ranexa has not been studied in children.

Side Effects of Ranexa

The following are the major possible risks and side effects of Ranexa therapy:

  • QT prolongation. Ranexa may cause this serious heart beat problem which can lead to sudden death.
  • dizziness and lightheadedness. Do not drive a car or operate machinery until you know how Ranexa affects you. Call your healthcare professional if you have heart beat problems (palpitations) or fainting spells.
  • Some common side effects with Ranexa include:
    • headache
    • constipations
    • nausea

Who Should Not Take Ranexa

Do not take Ranexa if you:

  • have a heart problem called QT prolongation
  • have or had liver problems
  • are taking other medicines that also cause QT prolongation. Some of these medicines are:
    • antiarrhythmic medicines including quinidine, dofetilide (Tikosyn), sotalol (Betapace)
    • erythromycin
    • certain antipsychotic medicines including thioridazine (Mellaril), ziprasidone (Geodon)
  • are taking medicines or foods that can interact with Ranexa. Some of these include:
    • ketoconazole (Nizoral) and certain other antifungal medicines
    • diltiazem (Cardiazem, Dilacor, Tiazac)
    • verapamil (Calan, Verelan, Covera HS)
    • macrolide antibiotics
    • HIV protease inhibitors
    • grapefruit juice or grapefruit containing products

Interactions with Ranexa

See “Who should not take Ranexa?” for more information. Other medicines not listed in that section can also interact with Ranexa including:

  • digoxin (Lanoxin, Lanoxicaps)
  • simvastatin (Zocor)
  • ritonavir (Norvir)
  • cyclosporine (Gengraf, Neoral, Restasis, Sandimmune)
  • antidepressant medicines
  • antipsychotic medicines

Tell your healthcare professional about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Know the medicines you take. Keep a list of them with you to show your healthcare professional.

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Recent Forum Posts on Ranexa

Surprpising experience with Ranexa

I very recently was prescribed Ranexa by my Cardiologist. I took the medication as directed, one pill - 500 mg in the A.M and one 500 mg pill in the P.M. I did this for four and one-half (4 1/2) days. I felt fine . Noticed no difference whatsoever. I had read the indications about side effects. No where did I see anything to do with driving a car. On the fourth day I had a long trip to my GP (he is located 42 miles one way, away). I started almost immediately weaving in my own lane and a few times ran over the right side fog line and several times over the middle yellow line including a double yellow line. I kept wondering what was wrong. I "felt" fine otherwise. At the doctors, I had a magazine "slip" out of my hand a couple times, I tried to write a note and it was completely illegible - than I thought that perhaps I was actually having a stroke. When I saw the Dr. and told him all this, and showed him my note pad, he said to STOP the Ranexa immediately. I was having side effects to the Ranexa. I had no choice but to drive myself home after our office visit was concluded. Again, but more exaggerated and more often I experienced what I had on the way over. Talk about scary!!! In my mind I was fine but my body took over and I was not fine. I did not drive for a couple days and I am alright now. Have to find out what is nextom so far as my next medication. Needless to say, I am slightly "gun shY". Read and then read some more.And for God Sakes, DO NOT stay on the highway as I foolishly did.:confused:http://www.iddb.org/forums/images/smilies/confused.gif

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