Sprycel

The below information on Sprycel has been taken from official FDA sources, but we cannot guarantee it's accuracy. Please use this site for educational purposes only. This site does not replace a proper discussion with your doctor.


    Brand Name:Sprycel
    Generic:Dasatinib
    Availability:Prescription
This drug was approved by the FDA in one form or another on:
2006-06-28 ,
This drug is made in one form or another by the following companies:
Bristol-Myers Squibb
This drug is available in the following forms:
Tablets
View the actual FDA approved label for this drug at the following links:
http://www.fda.gov/cder/foi/label/2006/021986lbl.pdf

About Sprycel

Sprycel is a prescription medicine used to treat adults who:

  • have chronic myeloid leukemia (CML)
  • have acute lymphoblastic leukemia (ALL) called Philadelphia chromosome positive or Ph+ALL
  • are no longer benefiting from treatment with the current available therapies for these diseases including a medicine called Gleevec (imatinib mesylate)
  • experience severe side effects from Gleevec and are no longer able to take it

The long term benefits and toxicities are currently still being studied.

Sprycel has not been studied in children.

Side Effects of Sprycel

  • Low Blood Counts. Sprycel may cause low red blood cell counts (anemia), low white blood cell counts (neutropenia), and low platelet counts (thrombocytopenia). Your healthcare professional will monitor your blood counts frequently after your start Sprycel, and may adjust your dose of Sprycel or withhold the drug temporarily in the event your blood counts drop too low. In some cases, you may need to receive transfusions of red blood cells or platelets. Notify your healthcare professional immediately if you develop a fever while taking Sprycel.
  • Bleeding: Sprycel may cause bleeding. The most serious bleeding events observed in clinical studies included bleeding into the brain leading to death in 1% of patients, and bleeding from the gastrointestinal tract. Less severe events included bleeding from the nose, the gums, bruising of the skin, and excessive menstrual bleeding. Notify your healthcare professional immediately if you experience bleeding or easy bruising while taking Sprycel.
  • Fluid Retention: Sprycel may cause fluid to accumulate in your legs and around your eyes. In more severe cases, fluid may accumulate in the lining of your lungs, the sac around your heart, or your abdominal cavity. Notify your healthcare professional immediately if you experience swelling, weight gain, or increasing shortness of breath while taking Sprycel.
  • Some common side effects that may occur with Sprycel include:
    • diarrhea
    • skin rash
    • headache
    • fatigue
    • nausea

Who Should Not Take Sprycel

You should not take Sprycel if you:

  • have not previously had a trial of Gleevec (imatinib mesylate)
  • are pregnant or planning to become pregnant

Interactions with Sprycel

Sprycel and certain other medicines can interact with each other. Tell your healthcare professional about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Know the medicines you take. Keep a list of them with you to show your healthcare professional.

Sprycel is eliminated from your body through the liver. The use of certain other medicines may alter the levels of Sprycel in your bloodstream. Likewise, levels of other medicines in your bloodstream can be affected by Sprycel. Such changes can increase the side effects, or reduce the activity of the medicines you are taking, including Sprycel.

Especially tell your healthcare professional if you take:

  • medicines that increase the amount of Sprycel in your bloodstream, such as Nizoral (ketoconazole), Sporanox (itraconazole), Norvir (ritonavir), Reyataz (atazanavir sulfate), Crixivan (indinavir), Viracept (nelfinavir), Invirase (saquinavir), Ketek (telithromycin), E-Mycin (erythromycin), and Biaxin (clarithromycin).
  • medicines that decrease the amount of Sprycel in your bloodstream, such as Decadron (dexamethasone), Dilantin (phenytoin), Tegretol (carbamazepine), Rimactane (rifampicin), and Luminal (Phenobarbital).
  • medicines whose blood levels might be altered by Sprycel, such as Sandimmune (cyclosporine), Alfenta (alfentanil), fentanyl, Orap (pimozide), Rapamune (sirolimus), Prograf (tacrolimus), and Ergomar (ergotamine).
  • medicines that reduce stomach acid, such as Tagamet (cimetidine), Pepcid (famotidine), Zantac (ranitidine), Prilosec (omeprazole), Protonix (pantoprazole), Nexium (esomeprazole), Aciphex (rabeprazole), and Prevacid (lansoprazole).
  • medicines that neutralize stomach acid, such as Maalox (aluminum hydroxide/magnesium hydroxide), Tums (calcium carbonate), Rolaids (calcium carbonate and magnesia.
  • medicines that thin the blood, such as Coumadin (warfarin sodium) and aspirin.
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