The below information on Symbyax has been taken from official FDA sources, but we cannot guarantee it's accuracy. Please use this site for educational purposes only. This site does not replace a proper discussion with your doctor.

    Brand Name:Symbyax
    Generic:Fluoxetine Hydrochloride, Olanzapine
This drug was approved by the FDA in one form or another on:
2003-12-24 ,
This drug is made in one form or another by the following companies:
Eli Lilly and Company
This drug is available in the following forms:
View the actual FDA approved label for this drug at the following links:

About Symbyax

  • Symbyax contains two medicines, olanzapine and fluoxetine. Olanzapine is in a class of medications called atypical antipsychotics. Antipsychotic medicines are used to treat symptoms of schizophrenia that may include hearing voices, seeing things, or sensing things that are not there, mistaken beliefs or unusual suspiciousness. Fluoxetine is in a class of medications called selective serotonin reuptake inhibitors (SSRIs). It is used to treat depression, obsessive-compulsive disorder, bulimia, and panic disorder.
  • Symbyax is used to treat adults who have depression with bipolar disorder. Bipolar disorder is a mental illness that causes extreme mood swings.

Precautions for Symbyax

  • Dizziness, and sometimes fainting, caused by a drop in blood pressure may happen with Symbyax, especially when you first start taking this medicine or when the dose is increased.
  • Symbyax may impair judgment, thinking, or motor skills. You should be careful in operating machinery, including automobiles, until you know how Symbyax affects you.
  • It is important to avoid overheating and dehydration while taking Symbyax. Symbyax may make it harder to lower your body temperature.

Side Effects of Symbyax

Symbyax can cause serious problems such as:

  • Suicidal thoughts or actions. Persons taking Symbyax may be more likely to think about killing themselves or actually try to do so, especially when Prozac is first started or the dose is changed. People close to persons taking Prozac can help by paying attention to changes in user’s moods or actions. Contact your healthcare professional right away if someone using Prozac talks about or shows signs of killing him or herself. If you are taking Prozac yourself and you start thinking about killing yourself, tell your healthcare professional about this side effect right away.
  • Increased chance of death in elderly persons. Elderly patients treated with atypical antipsychotics, such as Symbyax, for dementia had a higher chance for death than patients who did not take the medicine. Symbyax is not approved for dementia.
  • A life-threatening nervous system problem called neuroleptic malignant syndrome (NMS). NMS can cause a high fever, stiff muscles, sweating, a fast or irregular heart beat, change in blood pressure, and confusion. NMS can affect your kidneys. NMS is a medical emergency. Call your healthcare professional right away if you experience these symptoms.
  • A movement problem called tardive dyskinesia (TD). Call your healthcare professional right away if you get muscle movements that cannot be stopped.
  • High blood sugar and diabetes. Patients with diabetes or who have a higher chance for diabetes should have their blood sugar checked often.
  • Strokes have happened in older patients treated for mental illness from dementia. Symbyax is not approved for this use.
  • Bleeding problems. Symbyax may cause bleeding problems, especially if taken with aspirin, NSAIDs (nonsteroidal antiinflammatory drugs, such as ibuprofen or naproxen), or other drugs that affect bleeding.
  • Sexual problems. You may have problems with impotence (erectile dysfunction), abnormal ejaculation, difficulty reaching orgasm, or decreased libido (sexual desire).
  • Mania. You may become hyperactive, excitable or elated.
  • Low salt levels in the blood. Weakness, confusion, or trouble thinking can be caused by low salt levels in the blood.
  • Other serious side effects may include low blood pressure seen as dizziness, and possibly fainting; increased heart beat; seizures; liver problems; increased body temperature; and difficulty swallowing.
  • The most common side effects include sleepiness, dry mouth, dizziness, restlessness, diarrhea, weight gain, increased appetite, and tremor.

Who Should Not Take Symbyax

Never take Symbyax if you are taking another drug used to treat depression, called a Monoamine Oxidase Inhibitor (MAOI), or if you have stopped taking an MAOI in the last 14 days. Taking Symbyax close in time to an MAOI can result in serious, sometimes fatal, reactions, including:

  • High body temperature
  • Coma
  • Seizures (convulsions)

Do not take a MAOI within 5 weeks of stopping Symbyax. MAOI drugs include Nardil (phenelzine sulfate), Parnate (tranylcypromine sulfate), Marplan (isocarboxazid), and other brands.

Never take Symbyax if you are taking Mellaril (thioridazine), used to treat schizophrenia. Also, do not take Mellaril within 5 weeks of stopping Symbyax. Taking Symbyax close in time to Mellaril can result in serious heart beat problems.

Interactions with Symbyax

Because certain other medications can interact with Symbyax, review all medications that you are taking with your healthcare professional, including those that you take without a prescription.

Your healthcare professional may have to adjust your dose or watch you more closely if you take the following medications:

  • blood pressure medicines
  • levodopa and other medicines called dopamine agonists
  • omeprazole
  • rifampin
  • carbamazepine
  • fluvoxamine
  • clozapine
  • haloperidol
  • phenytoin
  • lithium
  • pimozide
  • sumatriptan
  • warfarin

Avoid drinking alcohol while taking Symbyax.

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Recent Forum Posts on Symbyax


I have just been given a prescription for symbyax. My doctor said it would make me sleep for the first 3 days. I am wondering if this was the case for anyone else. Or if any one can tell me what the first week or two was like while getting on the medication.

No Subject

I have been on Symbyax for about a month now. I am currently taking 3/25. I am concerned that this is no strong enough because my bi-polar depression has not subsided as I think it should with medication.

No Subject

I have been on Symbyax for nearly 3 weeks, to treat bipolar depression.

It has worked wonders, and began working very fast, within days! I have not had any weight gain, and that's what I was worried about. I feel great for the first time in years.

It works great

Symbyax is a combo of Prozac and Zyprexa. According to my doctor, it is a very powerful anti-depressant for bi-polar depression which I have. It worked as quick as one week, much faster than Seroquel. Also, I am on the 6/25 dose which, again from my doctor, said is the dose most people with my condition have. I got my life back and decided that any side effects I have had can wait because now I enjoy life again and my family enjoys me again. I have been on it for 4 months and it is been great.

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