Tikosyn

The below information on Tikosyn has been taken from official FDA sources, but we cannot guarantee it's accuracy. Please use this site for educational purposes only. This site does not replace a proper discussion with your doctor.


    Brand Name:Tikosyn
    Generic:Dofetilide
    Availability:Prescription
This drug was approved by the FDA in one form or another on:
1999-10-04 ,
This drug is made in one form or another by the following companies:
Pfizer
This drug is available in the following forms:
Capsules
View the actual FDA approved label for this drug at the following links:
http://www.fda.gov/cder/foi/appletter/1999/20931ltr.pdf

About Tikosyn

Tikosyn is a medicine that is given to patients with irregular heartbeats (atrial fibrillation). Tikosyn may help the heart beat more regularly and stay beating regularly for a longer period of time.

Precautions for Tikosyn

Tell your doctor about any problems you have with your:

  • heart
  • kidneys
  • liver

Side Effects of Tikosyn

Tikosyn’s most serious side effect, the different type of dangerous abnormal heartbeat is described in the "Special Warnings" section.

Other common side effects of Tikosyn are:

  • Headache
  • Chest pain
  • Dizziness

Who Should Not Take Tikosyn

You should not take Tikosyn if you:

Are taking certain other medicines, including:

  • cimetidine (TAGAMET, TAGAMET HB)®, used to treat heartburn, upset stomach, and stomach ulcers, available both by prescription and without a prescription
  • verapamil (CALAN, CALAN SR, COVERA-HS, ISOPTIN, ISOPTIN SR, VERELAN, VERELAN PM)®, used to treat high blood pressure and certain heart problems
  • ketoconazole (NIZORAL)®, used to treat certain fungus infections
  • trimethoprim alone (PROLOPRIM, TRIMPEX)® or the combination of trimethoprim and sulfamethoxazole (BACTRIM, SEPTRA)®, used to treat certain bacterial infections
  • prochlorperazine (COMPAZINE)®, used to treat nausea and vomiting
  • megestrol (MEGACE)®, used to treat certain types of cancer or loss of appetite
  • and weight loss associated with AIDS

Have serious kidney problems or are on kidney dialysis.

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Recent Forum Posts on Tikosyn

Quitting Tikosyn

I take 250 micro-grams 2x/day and would like to stop taking Tikosyn. My atrial fib. was caused by alcohol consumption but it was to late that I discovered this fact and by then the episodic a. fib. had converted to a permanent condition.(By the way the a.Fib. started 3 to 4 hrs after the last drink.) Tikosyn converted my heart to a normal sinus rhythm. I'd like to hear from patients/physicians that had the stopped the drug and to share their experiences. (I am a pharmacologist so please do not hesitate to answer in the manner any medical scientist would understand.)All experiences are welcome and I thank you in advance.


Quitting Tikosan

I take 250 micro-grams 2x/day and would like to stop taking Tikosyn. My atrial fib. was caused by alcohol consumption but it was to late that I discovered this fact and by then the episodic a. fib. had converted to a permanent condition.(By the way the a.Fib. started 3 to 4 hrs after the last drink.) Tikosyn converted my heart to a normal sinus rhythm. I'd like to hear from patients/physicians that had stopped the drug and to share their experiences. (I am a pharmacologist so please do not hesitate to answer in the manner any medical scientist would understand.)All experiences are welcome and I thank you in advance.


Tikosyn and Monopril

I have just stated taking Tikosyn around Thanksgiving and since then my blood preasure has shot up, before starting Tikosyn I was taking Monopril for high blood preasure and it was under control. Does anyone know if these two drugs work together?


weight gain

I really do not believe I am eating more and do do daily excersie, but I feel I have also gained weight while I have been on tikosyn this past year and will be on it up to two years in April. Have there been others who feel as I do? Any suggestions?


terrible side effects

my husband started taking tikosyn for atrial fibrillation on aug 2 2004 under a 3 day monitoring period spent in the hospital. he was fine until, approximately sept sept 23rd 2004. he began to experience an irregular heartbeat, fatigue, shortness of breath, stomach pain. he went for checkup on sept 30, 2004. dr was cardiologist was mystified and thought it was related to mis-setting of pace maker. went back on oct 14, 2004 and had now developed edema in ankles. dr took him off tikosyn. here we are on nov 25, 2004 with some subsiding of symptoms but not all gone. this is a man who was leading a normal active life until starting tikosyn and never experienced any of the above symptoms. after really researching, found that 2-3% experience them. why are they not mentioned in full in accompanying leaflet? why was physician not aware of these classic symptoms as adverse side effects? will my husband ever get back to the healthy active man he was pre-tikosyn?


Tikosyn

Following many years of AF,I began Tikosyn(250mcg)in August, 2005 at age 73, and converted to normal sinus rhythm about 3 days after release from the hospital. So far, there have been no recurrances of AF nor side effects other than reduction in heart rate from around 100 to 40-50. Other drugs I am taking are Warfarin, Altace, Metoprolol and Lipitor and there have been no problems with them.


No Subject

I have been on Tikosyn for almost two years. Started out ok. Then I had a few episodes of rapid heart beat. It got even more frequent. I quit drinking alcohol seven months ago the episodes are even more frequent now. Sometimes as many as three a day lasting fron minutes to hours. I take .5mg of Alprasolam when this happens and it helps curb the attack of rapid heart beat. I'm a 55 year old male. I've also noticed that I have these attacks after I eat, especialy sweets. Does anyone else have a simular situation? I take .250mg twice daily.


leg and knee pain with tikosyn

my husband has been on tikosyn for nearly 2 years. he has a lot of leg and knee pain . wonder if it is related to the drug!


No Subject

I have been until recently very active (hiking, bicycling,swimming, etc.
During the last 12 months I had 4 episodes of artrial fibrilation. I saw a
cardiologist who subsequently recommended Tikosyn which I am taking now.
Frankly - I don't like the medication. Side effects are: very tired,
chest pains, drowsiness, loss of appetite.
I am 70 and as mentioned above have been active and now this - no way! I
am going off this medication.


Tachacardia

I have been taking Tikosyn for 2 years, and the only sideaffects that I've
noticed, is loss of appetite. I also have an ICD Defibulater.


Tikosyn

I had experienced constant afib for over 12 months. One hour after my first dose of Tikosyn the afib stopped and a healthy heart rythm began. My pulse is low (low 40) but I am physically in good shape and feel this may have been the norm a few years ago before this all started. This is only my third day on Tikosyn but I am very encouraged


Rapid Heartbeat

My Cardioligist prescribed 250mg Tikosyn two times per day. I started taking them 07-22-2004 and kept getting a rapid heartbeat every morning getting worse every day when finally Sunday morning 08-08 2004 I was showering and I had to rest before I could finish I took them two more days before calling my Doctor to tell him about my reaction and he advised me to go off them.


Weight Gain

I have been on Tikosyn since 6/03 and feel wonderful except for weight gain and increase in appetite. I have been told by my physicians that this is not one of the side effects but I was the same weight for 3 and a half years before starting this medication. I recently started taking Zoloft to help curb my appetite with some success but still have craving somewhat.


Availability

Our family member has been successfully treated with Tikosyn for two years, but following an attack of fibrillation last evening he tells us that Tikosyn is available only through Canada and he can no longer get it. Is this true? Why is this?


Tikosyn side effect

Could prolonged use of this drug cause swelling of the lymph nodes in the neck?


tikosyn

I have been in constant afib for at least a year, have had 3 cardio versions, tried sotalol and tambacor, nothing worked until tikosyn. I have been on it for one month now and have stayed in constant sinus rhythm with no side effects, I have more energy than before. I am a 47 year old male.


No Subject

Have been on tikosyn for over a year. Too many side effets with other drugs so have to take this one. Had two ablations and tried every other drug my electrcardiologist knew of. On one drug my heart stopped. Very scary. On other drugs my heart would beat very fast then very slowly. I wish I was not taking it but am stuck with it. Am also taking a beta blocker.


Side Effects Ringing in Ears

I have been taking Tikosyn for 2 1/2 months. I am experiencing the advertized side effects: slight headache, chest pain (different from chect pain I felt while in A-Fib), and occasional dizziness. I have recently experienced contiunuous ringing in my ears. I do not know if this is another side effect of the tikosyn or if there is some other cause. Has anyone else experienced this side efect (ringing in ears?). RG



tikosyn

I have been on Tikosyn for 3 months. I had a Cardio Version in October and ever since then have had a severe headache. but my heart is in rythum. Plus I thing it makes me depressed.


No Subject

I have been on this medication for three months. Previously I had recurrent episodes of atrial fibrillation often lasting for days and treated eventually with cardioversions. I also have an ICD for right ventricular dysplasia and the serious arrythmias associated with that diagnosis. I find that I am very tired and have gained about 10 pounds since I have been on the medication. It is effective in that I am not having prolonged atrial fibrillation. However, I have very little energy and in the last three days have developed a number of hives.


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