Wellbutrin XL

The below information on Wellbutrin XL has been taken from official FDA sources, but we cannot guarantee it's accuracy. Please use this site for educational purposes only. This site does not replace a proper discussion with your doctor.

    Brand Name:Wellbutrin XL
    Generic:Bupropion Hydrochloride
This drug was approved by the FDA in one form or another on:
2003-08-29 ,
This drug is made in one form or another by the following companies:
This drug is available in the following forms:
Tablets, Extended Release
View the actual FDA approved label for this drug at the following links:

About Wellbutrin XL

Bupropion is a medicine that is used to treat depression.

Side Effects of Wellbutrin XL

  • Suicidal Thoughts or Actions: See FDA Alert.
  • Seizures: Bupropion can cause seizures. See "Who should not take bupropion?" You also have a higher chance for seizures with bupropion if you take a higher dose, had a head injury, brain tumor, severe liver disease, abuse alcohol or drugs, or take certain medicines that interact with bupropion. Stop bupropion if you have a seizure and never take it again.
  • Possible liver damage
  • Serious allergic reactions: Call your healthcare professional right away if you get a skin rash, hives, chest pain, swelling, or trouble breathing.
  • Agitation, anxiety, and trouble sleeping
  • Mental problems, including psychosis, confusion and hallucinations.
  • Mania: You may become hyperactive, excitable, or elated.
  • Weight and appetite change: More people lose weight, than gain it, while taking bupropion.
  • High Blood Pressure (hypertension). The chance for high blood pressure is increased if you also use nicotine replacement products to stop smoking.
  • Other side effects include agitation, dry mouth, trouble sleeping, headache and migraine, nausea and vomiting, constipation, and tremor
  • Tell your healthcare professional about all your medical conditions, especially if you have liver, kidney, or heart disease. Tell your healthcare professional if you are pregnant or plan to become pregnant. Tell your healthcare professional if you are breast-feeding or plan to breast-feed your baby.

Who Should Not Take Wellbutrin XL

  • Never take bupropion if you are taking another drug used to treat depression, called a Monoamine Oxidase Inhibitor (MAOI), or if you have stopped taking a MAOI in the last 14 days. Taking bupropion close in time to a MAOI can result in serious, sometimes fatal, reactions, including:
    • High body temperature
    • Coma
    • Seizures (convulsions)

    MAOI drugs include Nardil (phenelzine sulfate), Parnate (tranylcypromine sulfate), Marplan (isocarboxazid) and other brands.

  • Bupropion can cause seizures. Never take bupropion if you have any of the following because you have a higher chance of having seizures with bupropion:
    • A seizure disorder
    • Take Zyban or any other medicine containing bupropion
    • A current or past eating disorder such as bulimia or anorexia nervosa
    • Stop suddenly, the use of alcohol or sedatives, including medicines for anxiety and sleeping problems called benzodiazepines.

Interactions with Wellbutrin XL

  • Bupropion may interact with medicines other than the ones already mentioned in this information sheet, causing serious side effects. Tell your healthcare professional about all the medicines, vitamins, and herbal supplements you take, especially those used for treating seizures, depression, mental illness, asthma, high blood pressure, or heart problems.
  • If you plan to drink alcohol, talk to your healthcare professional.
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Recent Forum Posts on Wellbutrin XL

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long term use

Well I LOVE the Wellbutrin XL. It is so tiny and easy to swallow. I have not had bad side effects To tell the truth, I take so many other Meds, that they all have similar side effects!!!
I do get horrible dry mouth, so carry a water bottle everywhere! Also keep hard candy in my purse, pappermint helps a lot, it is hard to talk with no saivia in your mouth~ If I forget my AM dose, I do have agitation and bad moods, so immediately go to my pill counter and see that I skipped the dosage, I have been on Wellbutrin for a very long time, say since 1980! I swear by it, and have had good success. I do not like to try something new, if this works for me!!! Good Luck!!!
PS Meditation and yoga help for depression.

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