The below information on Xeloda has been taken from official FDA sources, but we cannot guarantee it's accuracy. Please use this site for educational purposes only. This site does not replace a proper discussion with your doctor.

    Brand Name:Xeloda
This drug was approved by the FDA in one form or another on:
1998-04-30 ,
This drug is made in one form or another by the following companies:
Roche Laboratories, Inc.
This drug is available in the following forms:
View the actual FDA approved label for this drug at the following links:

About Xeloda

Xeloda is used to treat:

  • cancer of the colon or rectum that has spread to other parts of the body (metastatic colorectal cancer) when fluoropyrimidine therapy alone is preferred. Patients and physicians should note that combination chemotherapy has shown a survival benefit compared to 5-fluorouracil (5-FU)/oral leucovorin ( LV ) alone. A survival benefit over 5-FU/LV has not been demonstrated with Xeloda monotherapy.
  • Dukes’ C colon cancer in patients who have had complete removal of the tumor when treatment with fluoropyrimidine therapy alone is preferred. Although neither Xeloda nor combination therapy prolongs overall survival, combination chemotherapy has shown a survival benefit compared to 5-FU/LV alone.
  • breast cancer that has spread to other parts of the body and has not responded to treatment with certain other medicines. These medicines include paclitaxel (Taxol) and anthracycline-containing therapy such as Adriamycin and doxorubicin.

Xeloda is changed in the body to the substance 5-fluorouracil. In some patients with colon, rectum or breast cancer, this substance stops cancer cells from growing and decreases the size of the tumor.

Precautions for Xeloda

Xeloda can cause tingling, numbness, pain, swelling, or redness in the palms of your hands or soles of your feet (hand and foot syndrome). Stop taking Xeloda and contact your doctor if you have signs of this syndrome. Your doctor may want to decrease your dose or stop your treatment with Xeloda.

Side Effects of Xeloda

  • diarrhea (see warnings)
  • nausea - stop taking Xeloda and contact your doctor if you are not able to eat or are only able to eat at certain times.
  • vomiting - stop taking Xeloda and contact your doctor if you vomit 2-5 times or more in a 24-hour period.
  • sores in mouth and throat - stop taking Xeloda and contact your doctor if you have painful swelling and ulcers in your mouth or tongue.
  • stomach pain
  • decreased appetite
  • dehydration
  • hand-and-foot syndrome (see general precautions)
  • rash
  • dry or itchy skin
  • tiredness
  • dizziness
  • headache
  • fever - contact your doctor if you have a fever of 100.5°F or higher.

These side effects may differ when taking Xeloda in combination with Taxotere® or in combination with other chemotherapy. Please consult your doctor for possible side effects that may be caused by taking Xeloda with Taxotere or other chemotherapies.

Who Should Not Take Xeloda

  • You should not take Xeloda if you are allergic to 5-fluorouracil (5-FU) because Xeloda is converted by the body to 5-FU.
  • You should not take Xeloda if you have severe renal impairment.
  • You should not take Xeloda if you are nursing a baby. Xeloda may pass into the milk and harm the baby.
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Recent Forum Posts on Xeloda

Just started XELODA

~~~ HELLO IDDB COMMUNITY ~~~ Just started a regiment of three drugs ~ ...including Avastin (IV) and XELODA, pills. I have to look around and find the name of the other IV drug. About 6 hours on my first visit. Was shaking all over the place: (couldn't hold a 1/2 cup of coffee before infusion began because of apprehension.) But within an hour I was calmed down and it wasn't at all bad. No side-effects so far except.... that I had the reverse side-effects of XELODA. Supposedly you can get faint, or weak, or sleepy, etc etc. But I got :eek: HYPER. Twas great!!! Felt like 22 years old all over again. Ready to talk to every neighbor on the street and find out their life's histories. Party time if I could find one. :cool: Came up with a screen play for a Sci-Fi movie which I related to a writer/teacher friend on the phone. Maybe this is a fluke. Tomorrow I meet with my regular Doctor and will find out what's happening so far. Cancer was removed via surgery from rectal and colon. But it moved up to the liver and there are altogether four small spots on the lobes. If there had been a liver surgeon present during the operation, they likely would have lasered it away. But no show that time of surgery. The Doc says Avastin will knock it out along with XELODA. XELODA turns into something like the 5FU drug, or turns into the 5FU drug itself. Have to read up on it all. :) Good chance for full recovery during the year.


I have been on Xeloda for about 3 months. I have invasive lobular breast cancer that has spread to my ovaries, liver and groin. It was in my thorasic spine, but chemo and God took that one.
Xeloda is sort of my last hope since I have had so many infusions.
My cancer has not grown, but we will know more next month when I do another PET test. Xeloda makes me extremely tired, a little nauseaus, bad hand and foot syndrome, but I still go to work. I have tried utter cream, hydrocordizone cream, just about anything that will help. I dress according to what shoes I can wear. I have a pair of houseshoes under my desk. I think xeloda is great because it is chemo in a pill form, but I pray for the day when scientist can help with the side effects of chemo. I am 44 and if I have to live my life sick, or unable to function due to chemo, I will quit taking it and go home to my Lord.
Thank you to those of you who work so hard to find cures and treatments. I lost a brother to a brain tumor, my dad is dying of lung cancer and my sister had breast cancer but is in remission. Hers was a different type. I hate to see people suffer and I pray for the children who have to go through any of the treatments and surgeries I have had.
Thank You.

joint pain & swelling with Xeloda

Have any of you experienced swelling and pain in your joints while taking xeloda? Mine is in hands, wrists, feet & ankles.
If you have had it what treatment have you used for it?


What are the tests I should ask my oncologist to be running before starting the Xeloda? Also, what is the safe dosage?

I have Stage IV breast cancer, gone to my membrane between brain and skull, that's the reasoning.

Any scientific studies out there to warrant continuing Herceptin along with Xeloda/Tykber (have HER2neu+++)?

Safe to take B6 to try to ward off the hand/foot side effect?


Please be careful when taking Xeloda, my mom had a very severe reaction to Xeloda and ended up in ICU. She is lacking a particular enzyme that breaksdown the 5FU in Xeloda. This has caused a severe case of mucositis and all of her blood counts to drop. When admitted to ICU, they couldnt get a reading on her blood pressure. She had excessive bleeding that required constant suctioning from her mouth and lungs. It is a horrible, horrible thing. Has anyone else experienced this?

Pancreatic Cancer

I read your comments and wondered if your father took Xeloda for the treatment of his cancer. My father was diagnosed with pancreatic cancer on the 28th of July and had the Whipple procedure done to remove part of his pancreas, small intestine, stomach, and gall bladder. Did your father respond well to the chemo and radiation?

pancreatic cancer

My dad was diagnosed with bile duct obstruction and pancreatic cancer stage IV in June 2002. He was started on Gemzar IV and Xeloda orally. He has done well on this combination; he has had more problems with bile duct stents than with chemo side effects. He has good quality of life except for overall decrease in energy. Actually now that he has slowed down from his previously full time schedule as owner and manager of a hardware business for 56 years he notices a little arthritis. He celebrated his 78th birthday March 2003 and is looking forward to the birth of his first great grandchild in November.

His CT scan shows tumor suppression; and the tumor markers are down.
I am thankful for the oncologist who offered us the option to participate in this research study. If you have questions please email me.

xeloda & colon cancer

My brother was diagnosed last August with stage IV colon cancer with liver met's. He is 34yr's old and previously to his diagnosis he was in excellent physical shape which I think has helped him tremendously through what his oncologist says has been one of the hardest roads he has seen for a patient.

He too as the woman whose comments written before me has bile duct issues. There is tumors pushing on the duct and they were unable to get a stent placed so currently he has an external biliary bag.

He has been on a chemo regimine of two weeks on xeloda and two weeks off with once a week chemo via port. Just last week we were told his CEA levels are starting to drop. Oncologist said that was encouraging and that my brother has put on some weight. His days used to be all bad to horrible and now he is about 50 to 60% of the time feeling pretty well but the remainder 40-50% of the time is still pretty bad.

The worst is when he is on the xeloda for some reason he ends up in the hospital almost every time. He gets extreme stomach paid & pressure on the kidneys from the distention of his abdomin. When at the ER they take x-rays & usually find he is backed up with stool. They perscribe go-liteley and administer major paid med's while he endures high level pain. Other times he gets an illeus which is where his bowels start to go to sleep & they have to place an NG tube till they wake up again. Either way the pain he gets from either situation is 10+.

We would love to know what we could do to avoid this happening every single round of xeloda. If anyone out there has had similar experience due to xeloda and have any suggestions or know something that worked for them we of course are open to any input or suggestions.

If you have questions or comments e-mail me at:bat6302@msn.com.
Just put Xeloda for the Subject then I will know that the message is not junk mail.

high liuver function blood test

does xeloda raise high liver function I took it for 6.5 months


my husband has stomach and prostate cancer. he just started taking these. how will they help if the original chemo has not helped his tumor in any way?

No Subject

i am on xeloda as a single agent for Met Breast cancer, the side effects can be pretty rough. Red swollen hands and feet, weight gain, loss of taste and extreme fatigue. However, my last scan showed NED. If the next scan shows then same then I am going to take some time off of the medicine and try to enjoy my life.

No Subject

What about Xeloda and Pancreatic cancer? My dad has recently been diagnosed with this and Xeloda is one of the options (combined with Aggressive radiation) for treatment. Is there any data in this area? The Cancer is localized at the head, and has NOT spread outside the Pancreas.

I look forward to your response.

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