The below information on Xeloda has been taken from official FDA sources, but we cannot guarantee it's accuracy. Please use this site for educational purposes only. This site does not replace a proper discussion with your doctor.
|This drug was approved by the FDA in one form or another on:|
|This drug is made in one form or another by the following companies:|
Roche Laboratories, Inc.
|This drug is available in the following forms:|
|View the actual FDA approved label for this drug at the following links:|
Xeloda is used to treat:
- cancer of the colon or rectum that has spread to other parts of the body (metastatic colorectal cancer) when fluoropyrimidine therapy alone is preferred. Patients and physicians should note that combination chemotherapy has shown a survival benefit compared to 5-fluorouracil (5-FU)/oral leucovorin ( LV ) alone. A survival benefit over 5-FU/LV has not been demonstrated with Xeloda monotherapy.
- Dukes’ C colon cancer in patients who have had complete removal of the tumor when treatment with fluoropyrimidine therapy alone is preferred. Although neither Xeloda nor combination therapy prolongs overall survival, combination chemotherapy has shown a survival benefit compared to 5-FU/LV alone.
- breast cancer that has spread to other parts of the body and has not responded to treatment with certain other medicines. These medicines include paclitaxel (Taxol) and anthracycline-containing therapy such as Adriamycin and doxorubicin.
Xeloda is changed in the body to the substance 5-fluorouracil. In some patients with colon, rectum or breast cancer, this substance stops cancer cells from growing and decreases the size of the tumor.
Precautions for Xeloda
Xeloda can cause tingling, numbness, pain, swelling, or redness in the palms of your hands or soles of your feet (hand and foot syndrome). Stop taking Xeloda and contact your doctor if you have signs of this syndrome. Your doctor may want to decrease your dose or stop your treatment with Xeloda.
Side Effects of Xeloda
- diarrhea (see warnings)
- nausea - stop taking Xeloda and contact your doctor if you are not able to eat or are only able to eat at certain times.
- vomiting - stop taking Xeloda and contact your doctor if you vomit 2-5 times or more in a 24-hour period.
- sores in mouth and throat - stop taking Xeloda and contact your doctor if you have painful swelling and ulcers in your mouth or tongue.
- stomach pain
- decreased appetite
- hand-and-foot syndrome (see general precautions)
- dry or itchy skin
- fever - contact your doctor if you have a fever of 100.5°F or higher.
These side effects may differ when taking Xeloda in combination with Taxotere® or in combination with other chemotherapy. Please consult your doctor for possible side effects that may be caused by taking Xeloda with Taxotere or other chemotherapies.
Who Should Not Take Xeloda
- You should not take Xeloda if you are allergic to 5-fluorouracil (5-FU) because Xeloda is converted by the body to 5-FU.
- You should not take Xeloda if you have severe renal impairment.
- You should not take Xeloda if you are nursing a baby. Xeloda may pass into the milk and harm the baby.
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