The below information on Zoloft has been taken from official FDA sources, but we cannot guarantee it's accuracy. Please use this site for educational purposes only. This site does not replace a proper discussion with your doctor.

    Brand Name:Zoloft
This drug was approved by the FDA in one form or another on:
1991-12-30 ,
This drug is made in one form or another by the following companies:
This drug is available in the following forms:
Tablets and Oral Concentrates
View the actual FDA approved label for this drug at the following links:

About Zoloft

  • Depression
  • Obsessive-compulsive disorder (OCD)
  • Panic disorder
  • Posttraumatic stress disorder (PTSD)
  • Premenstrual dysphoric disorder (PTSD)
  • Social anxiety disorder (SAD)

Side Effects of Zoloft

The following are the major potential risks and side effects of Zoloft therapy. However, this list is not complete.

  • Possible life-threatening serotonin syndrome when used with triptan medicines.
  • Infant persistent pulmonary hypertension.
  • Suicidal thoughts or actions: Persons taking Zoloft may be more likely to think about killing themselves or actually try to do so, especially when Zoloft is first started or the dose is changed. People close to persons taking Zoloft can help by paying attention to changes in user’s moods or actions. Contact your healthcare professional right away if someone using Zoloft talks about or shows signs of killing him or herself. If you are taking Zoloft yourself and you start thinking about killing yourself, tell your healthcare professional about this side effect right away.
  • Stopping Zoloft: Do not stop taking Zoloft suddenly because you could get side effects. Your healthcare professional will slowly decrease your dose.
  • Bleeding problems: Zoloft may cause bleeding problems, especially if taken with aspirin, NSAIDs (nonsteroidal anti-inflammatory drugs, such as ibuprofen and naproxen), or other drugs that affect bleeding.
  • Mania: You may become unusually hyperactive, excitable or elated.
  • Seizures: You may experience a seizure (convulsion), even if you are not taking Zoloft close in time with an MAOI.
  • Weight loss: Zoloft can cause weight loss. Children who take Zoloft for a long time should have their growth and body weight measured regularly.
  • Pregnancy: Tell your healthcare professional if you are or may be pregnant (see FDA Alert [07/2006] above). In addition to the issue described in the alert, babies delivered to mothers taking Zoloft late in pregnancy have developed problems, such as difficulty breathing and feeding.
  • Sexual problems: You may have problems with impotence (erectile dysfunction), abnormal ejaculation, difficulty reaching orgasm, or decreased libido (sexual desire).
  • Other side effects include nausea, diarrhea, difficulty sleeping, dry mouth, and sleepiness.

Tell your healthcare professional about all your medical conditions, especially if you have liver or heart disease. Tell your healthcare professional if you are breast-feeding or plan to breast-feed your baby.

Who Should Not Take Zoloft

Never take Zoloft if you are taking another drug used to treat depression, called a Monoamine Oxidase Inhibitor (MAOI), or if you have stopped taking an MAOI in the last 14 days. Taking Zoloft close in time to an MAOI can result in serious, sometimes fatal, reactions, including:

  • High body temperature
  • Coma
  • Seizures (convulsions)

MAOI drugs include Nardil (phenelzine sulfate), Parnate (tranylcypromine sulfate), Marplan (isocarboxazid), and other brands.

  • Never take Zoloft if you are taking Orap (pimozide), a drug used to treat Tourette’s disorder, because it can result in serious heart beat problems.
  • Never take Zoloft oral concentrate if you are taking Antabuse (disulfiram), used to treat alcoholism, because Zoloft oral concentrate contains alcohol.

Interactions with Zoloft

  • Zoloft may interact with medicines other than the ones already mentioned in this information sheet. These interactions can cause serious side effects. Tell your healthcare professional about all medicines, vitamins, and herbal supplements you take, especially those
    • that affect bleeding
    • used to treat anxiety, mental illness, depression, or heart problems
  • If you plan to drink alcohol, talk to your healthcare professional.
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Recent Forum Posts on Zoloft

zoloft - no no!!!

I'm pleased other people found this drug to be "great'' for them!!

good for you - i have tried a few antidepressant's over the years

and i must say , zoloft was the main one that gave me an upset stomach, no real relief from any symptoms, it actually produced more anxiety , then i have ever had prior, it gave me tremors, made my head feel more like cotton wool.....etc etc

today , i have found the right one after many years, only drawback is.......it puts weight on like no ones business and unfortunatly causes me problems, with sex, ie mainly climaxing - buy hey
i'd rather be feeling good inside most of the day and be able to cope........with most things in LIFE- so what if i never feel that i have just had the best /release, love and closeness of my life!!! (thru sex)
sniff sniff!! - i never had a problem there before! medication

sorry guys zoloft wasn't for me but good luck to you all

best regards to all


chest tightning

I have been on zoloft for 6 years or more and I have never had a problem much with the side effects but I took my 200 mg today with a glass of water and my chest started tighning and I felt like I was having acid reflux. I have never had this happen to me an it really scared me and my boyfriend. why would water cause this to happen??
thank you,Renee

a life saver for me

Zoloft has been a real life saver for me
since my suicide attempt on 12/12/1994.
I was subsequently diagnosed with major depression.
Although I still occassionally suffer mood swings they are much redduced and most of the time i have been able to function..."normally".
Every day without a suicidal thought is a winner !!!
i have had many great experiences since 1994 such as falling in love and having a lasting relationship with a wonderful woman.
watching my daugWter, now 20, grow up without the curse of having a father who suicided.
etc etc

Side effects have been an issue but no comparrison to the state of major depressiion.
I have mainly been on a pension since 1994 but am basicallyu having a very happy life with much joy and peace.

I would be happy to respond to anyone with questions , comments etc via email.


ps i live in Bunbury, Western Australia

pps I must say thanks pfizer and all the researchers who made this avavilable !!!
(and i have no relationship to any drug company etc)

No Subject

i have depression, panic and anxiety disorders, and i was diagnosed with all when i was around 8 years old. i have tried lots of different medications, but this one seems to be the best for me.

I have been on zoloft for about 7 years now, and it has worked pretty well for me, when i remember to take it every day. there are times when i go without taking it just because i think i dont need it anymore, and then i fall into one of my episodes. i cant eat, i cant drink, i cant do anything but sleep. every time i have one of these episodes, it lasts a few days and i lose about 12 lbs.

zooloft does work... but you have to commit to take it everyday. if you stop taking it, you can get seizures... i know from experience. and it IS a proven side affect. so dont stop just because you think it isnt working for you anymore... if its not, talk to your doctor. maybe your dosage needs to be adjusted, and then it will work again.

best of luck.

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