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Old 12-02-2005, 06:00 AM
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My first round of Velcade (8 shots over a 2-week<br>period, followed by 10 days witout chemo) was relatively <br>mild. Indifference to food, fatigue and occasional <br>constipation were the most notable symptoms. <br><br>Round 2 of Velcade produced the same lethargy and occasional <br>loss of appetite, but by far the worst problems were pains <br>in the legs. These were scarcely noticeable during the <br>day hours, when I was active, but at their worst in the <br>middle of the night. After 4-5 hours of good sleep came <br>severe pains that caused me to toss and turn, without relief,<br>the rest of the night. Advil helped, and I took it about <br>every 4 hours. Pain was a keen, burning sensation from hips<br>to feet, and often seemed to center in the knees. It could <br>be described as similar to "careless leg" syndrome -- only <br>much more painful. <br><br>The nightime pains described started to ease off after two <br>weeks, during which time I felt frustrated and unable to be <br>comfortable in any position. On one occasion I got out of <br>bed and slept the remainder of the night in a cushy chair. <br><br>
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